Down sendromlu hastalarda tiroid fonksiyonlarının değerlendirilmesi
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Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Fırat Üniversitesi Tıp Fakültesi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Down sendromu en sık görülen kromozomal anomalidir. Bu bireylerde tiroid fonksiyon bozuklukları sık görülmektedir. Bu çalışmada, hasta- nemiz çocuk endokrinolojisi polikliniğine Down sendromu tanısı ile başvuran hastaların tiroid fonksiyon testlerinin değerlendirilmesi amaçlanmıştır. Gereç ve Yöntem: Aralık 2018-Şubat 2020 tarihleri arasında Çocuk Endokrinoloji polikliniğine başvuran Down sendromlu toplam 79 olgunun verileri retrospektif olarak değerlendirildi. Hasta dosyalarından tiroid uyarıcı hormon (TSH), serbest tiroksin (fT4), anti-tiroid peroksidaz (anti-TPO), anti-tiroglobülin (anti-Tg) bakılıp bakılmadığı kaydedildi. TSH ve fT4 düzeyi normal olan hastalar ötiroidi, TSH yüksek ve fT4 düşük olan hastalar aşikar hipotiroidi, TSH yüksek ve fT4 normal olan hastalar ise subklinik hipotiroidi olarak tanımlandı. Hashimoto tiroiditi (HT) tanısı ise tiroid otoan- tikorlarının (anti-TPO ve/veya anti-Tg) pozitifliği ile konuldu. Bulgular: Çalışmaya 42’si (%53,2) erkek, 37’si (%46,8) kız olmak üzere toplam 79 hasta alındı. Hastaların ortanca yaşı 5,16 (1,58-9,41) yıl idi. Çalışmaya dahil edilen 79 olgunun 16’sında (%20,2) aşikar hipotroidi, 28’inde (%35,5) subklinik hipotroidi, 35’inde (%44,3) ötiroidizm saptandı. 79 hastanın 52’ine anti-TPO ve/veya anti-Tg bakılmıştı. Bu hastaların 9’unda (%17,3) tiroid otoantikorları pozitif idi. Sonuç: Down sendromlu çocuklarda tiroid fonksiyon bozukluğu özellikle subklinik hipotroidi sık görülmektedir. Bu nedenle bu hastalara belli aralık- larla tiroid fonksiyon testlerinin bakılması uygun olacaktır.
Objective: Down syndrome is the most common chromosomal anomaly. Thyroid dysfunction occurs frequently in individuals with Down syndrome. In this study, it was aimed to evaluate the thyroid function tests of patients diagnosed with Down syndrome, who presented to the pediatric endocrino- logy polyclinic of our hospital. Material and Method: The data of a total of 79 patients with Down syndrome who presented to the pediatric endocrinology outpatient department between December 2018 and February 2020 were evaluated retrospectively. From the medical records of the patients, it was recorded whether the levels of thyroid stimulating hormone (TSH), free thyroxine (fT4), anti-thyroid peroxidase (anti-TPO), and anti-thyroglobulin (anti-Tg) were previo- usly measured. Patients with normal levels of TSH and fT4 were defined as euthyroid; patients with high levels of TSH and low levels of fT4 were diagnosed with overt hypothyroidism, and patients with high levels of TSH and normal levels of fT4 were diagnosed with subclinical hypothyroidism. The diagnosis of Hashimoto’s thyroiditis (HT) was made by the presence of the positivity of thyroid autoantibodies (anti-TPO and/or anti-Tg). Results: A total of 79 patients, 42 (53.2%) male and 37 (46.8%) female, were included in the study. The median age of the patients was 5.16 (1.58- 9.41) years. Overt hypothyroidism was found in 16 (20.2%) of the 79 cases included in the study, subclinical hypothyroidism was found in 28 (35.5%) and euthyroidism was found in 35 (44.3%). The presence of anti-TPO and/or anti-Tg was checked in 52 of the 79 patients. Thyroid autoanti- bodies were positive in 9 (17.3%) of these patients. Conclusion: Thyroid dysfunction, especially subclinical hypothyroidism, is common in children with Down syndrome. Therefore, it would be app- ropriate to perform thyroid function tests at regular intervals in these patients.
Objective: Down syndrome is the most common chromosomal anomaly. Thyroid dysfunction occurs frequently in individuals with Down syndrome. In this study, it was aimed to evaluate the thyroid function tests of patients diagnosed with Down syndrome, who presented to the pediatric endocrino- logy polyclinic of our hospital. Material and Method: The data of a total of 79 patients with Down syndrome who presented to the pediatric endocrinology outpatient department between December 2018 and February 2020 were evaluated retrospectively. From the medical records of the patients, it was recorded whether the levels of thyroid stimulating hormone (TSH), free thyroxine (fT4), anti-thyroid peroxidase (anti-TPO), and anti-thyroglobulin (anti-Tg) were previo- usly measured. Patients with normal levels of TSH and fT4 were defined as euthyroid; patients with high levels of TSH and low levels of fT4 were diagnosed with overt hypothyroidism, and patients with high levels of TSH and normal levels of fT4 were diagnosed with subclinical hypothyroidism. The diagnosis of Hashimoto’s thyroiditis (HT) was made by the presence of the positivity of thyroid autoantibodies (anti-TPO and/or anti-Tg). Results: A total of 79 patients, 42 (53.2%) male and 37 (46.8%) female, were included in the study. The median age of the patients was 5.16 (1.58- 9.41) years. Overt hypothyroidism was found in 16 (20.2%) of the 79 cases included in the study, subclinical hypothyroidism was found in 28 (35.5%) and euthyroidism was found in 35 (44.3%). The presence of anti-TPO and/or anti-Tg was checked in 52 of the 79 patients. Thyroid autoanti- bodies were positive in 9 (17.3%) of these patients. Conclusion: Thyroid dysfunction, especially subclinical hypothyroidism, is common in children with Down syndrome. Therefore, it would be app- ropriate to perform thyroid function tests at regular intervals in these patients.
Açıklama
Anahtar Kelimeler
Down sendromu, Hipotroidi, Tiroid, Down syndrome, Hypothyroidism, Thyroid
Kaynak
Fırat Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
28
Sayı
1
Künye
Karakaya, A. A., Ünal, E., Beştaş, A. ve Haspolat, Y. K. (2023). Down sendromlu hastalarda tiroid fonksiyonlarının değerlendirilmesi. Fırat Tıp Dergisi, 28(1), 17-21.
