Phytochemical analysis and biological activity of Corchorus olitorius L.: Quantitative analysis of bioactive compounds by LC–MS/MS, antibacterial, enzyme inhibition, and cytotoxic activities

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dc.authorid0000-0003-2993-2605en_US
dc.authorid0000-0002-0505-3190en_US
dc.authorid0000-0001-8946-647Xen_US
dc.contributor.authorAtalar, Mehmet Nuri
dc.contributor.authorErenler, Ramazan
dc.contributor.authorTurkan, Fikret
dc.contributor.authorAlma, Mehmet Hakkı
dc.contributor.authorDemirtaş, İbrahim
dc.contributor.authorBaran, Ayşe
dc.contributor.authorKandemir, Sevgi İrtegün
dc.date.accessioned2023-11-02T06:54:05Z
dc.date.available2023-11-02T06:54:05Z
dc.date.issued2023en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyoloji Ana Bilim Dalıen_US
dc.description.abstractIntroduction: Corchorus olitorius L. is a significant plant in folk medicine, therefore, research on phytochemistry with biological activity may reveal its potential use in drug development. Medicinal plants are valuable sources of drug materials as they include bioactive compounds known as secondary metabolites. Determination of bioactive compounds and biological activity of plants lead to understanding their potential in drug development. Methods: A quantitative analysis of the bioactive compounds in leaf, stem, and root extracts of C. olitorius L. was carried out with Liquid Chromatography-Mass Spectrometry (LC–MS/MS). Acetylcholinesterase (AChE) and Glutathione-S-Transferase (GST) enzyme inhibition and antibacterial effects were investigated using Mueller Hinton broth microdilution assay. The anticancer activity of C. olitorius leaves was evaluated by MTT assay using HDF, U87, Skov-3, and Caco-2 cell lines. Results: In the quantitative study, leaf extract exhibited the largest concentration of bioactive compounds, and cynarin (6.680 mg/g extract) and chlorogenic acid (5.605 mg/g extract) were the major products. The leaf, stem, and root extracts showed significant AChE and GST inhibition activity. The leaf extract displayed antibacterial activity against P. aeruginosa with the value of 2.2±0.1 (IC50, μg/ mL) in comparison to the standard (4.00±0.1 IC50, μg/ mL). The leaf extract displayed good antiproliferative activity against sk-ov-3 cell lines with values of 37.1% and 42.1% at 250 μg/mL and 500 μg/mL concentrations, respectively. Conclusion: C. olitorius has the potential to be a drug agent against cancer and microbial-induced diseases due to its effective bioactive compound contents.en_US
dc.identifier.citationAtalar, M. N., Erenler, R., Türkan, F., Alma, M. H., Demirtaş, İ., Baran, A. ve diğerleri. (2023). Phytochemical analysis and biological activity of Corchorus olitorius L.: Quantitative analysis of bioactive compounds by LC–MS/MS, antibacterial, enzyme inhibition, and cytotoxic activities. European Journal of Integrative Medicine, 62, 1-7.en_US
dc.identifier.doi10.1016/j.eujim.2023.102290
dc.identifier.endpage7en_US
dc.identifier.issn1876-3820
dc.identifier.scopus2-s2.0-85169031011
dc.identifier.scopusqualityQ1
dc.identifier.startpage1en_US
dc.identifier.urihttps://www.sciencedirect.com/science/article/pii/S1876382023000665?via%3Dihub
dc.identifier.urihttps://hdl.handle.net/11468/13027
dc.identifier.volume62en_US
dc.identifier.wosWOS:001070558000001
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorKandemir, Sevgi İrtegün
dc.language.isoenen_US
dc.publisherElsevier GmbHen_US
dc.relation.ispartofEuropean Journal of Integrative Medicine
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibacterial activityen_US
dc.subjectAnticancer effecten_US
dc.subjectCorchorus olitoriusen_US
dc.subjectEnzyme inhibitionen_US
dc.subjectQuantitative analysisen_US
dc.titlePhytochemical analysis and biological activity of Corchorus olitorius L.: Quantitative analysis of bioactive compounds by LC–MS/MS, antibacterial, enzyme inhibition, and cytotoxic activitiesen_US
dc.titlePhytochemical analysis and biological activity of Corchorus olitorius L.: Quantitative analysis of bioactive compounds by LC–MS/MS, antibacterial, enzyme inhibition, and cytotoxic activities
dc.typeArticleen_US

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