Paramagnetic contribution of serum iron to the spin-spin relaxation rate (1/T2) measured by MRI
[ X ]
Tarih
2002
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Springer Wien
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Spin-spin relaxation time T-2 values of serum with and without iron were measured by magnetic resonance imaging (MRI) to find the proton relaxivity of Fe(III) in serum. T-2 values in serum containing definite amounts of added iron were also measured before and after addition of ascorbic acid. The difference in the 1/T-2 of serum with and without ascorbic acid was used for recalculation of the added iron values, Recalculated iron values confirm that the difference in healthy serum is caused by iron only. In addition, in order to find the paramagnetic contribution of serum iron, T-2 values of iron-deficient, healthy and iron-overloaded serum were measured before and after addition of ascorbic acid. The difference in the 1/T-2 values was then applied to the calculation of the serum iron values. The consistency of iron values determined from the difference to those by autoanalyzer suggests that the differences in diseased serum also represent the paramagnetic contribution of serum iron. The data imply that serum iron content in healthy, iron-deficient and iron-overloaded serum may be assessed by MRI.
Açıklama
Anahtar Kelimeler
[No Keyword]
Kaynak
Applied Magnetic Resonance
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
22
Sayı
1
