Complete atrioventricular block associated with clozapine intoxication: case report
Yükleniyor...
Tarih
2019
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Turkish Journal of Pediatrics
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Clozapine is one of the atypical anti-psychotic drugs used in the treatment of resistant schizophrenia. Although cardiac side-effects are rare, it has been reported that there may be development of myocarditis, dilated cardiomyopathy, postural orthostatic hypotension and prolonged QT duration. Complete atrioventricular (AV) block is characterized by the inability to transmit all of the atrial signal to the ventricles. Causes may be congenital, idiopathic or acquired which are associated with surgery, infection, or muscle disease. AV block is extremely serious and permanent pacemaker insertion is usually necessary for all patients. Complete AV block may develop due to clozapine intoxication through increase in vagal tonus, sinoatrial node (SN) and the inhibition of atrioventricular node signalling. The case presented here is of a 15-year old female patient who developed AV total cardiac block associated with the taking of clozapine in a suicide attempt.
Açıklama
PMID: 31990485
Anahtar Kelimeler
Clozapine, Complete atrioventricular block, Intoxication
Kaynak
Turkish Journal of Pediatrics
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
61
Sayı
4
Künye
Türe, M., Bilici, M., Akın, A., Demir, F., Balık, H. ve Darakçı, S. M. (2019). Complete atrioventricular block associated with clozapine intoxication: case report. Turkish Journal of Pediatrics, 61(4), 618-621.
