Complete atrioventricular block associated with clozapine intoxication: case report

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Küçük Resim

Tarih

2019

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Turkish Journal of Pediatrics

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

Clozapine is one of the atypical anti-psychotic drugs used in the treatment of resistant schizophrenia. Although cardiac side-effects are rare, it has been reported that there may be development of myocarditis, dilated cardiomyopathy, postural orthostatic hypotension and prolonged QT duration. Complete atrioventricular (AV) block is characterized by the inability to transmit all of the atrial signal to the ventricles. Causes may be congenital, idiopathic or acquired which are associated with surgery, infection, or muscle disease. AV block is extremely serious and permanent pacemaker insertion is usually necessary for all patients. Complete AV block may develop due to clozapine intoxication through increase in vagal tonus, sinoatrial node (SN) and the inhibition of atrioventricular node signalling. The case presented here is of a 15-year old female patient who developed AV total cardiac block associated with the taking of clozapine in a suicide attempt.

Açıklama

PMID: 31990485

Anahtar Kelimeler

Clozapine, Complete atrioventricular block, Intoxication

Kaynak

Turkish Journal of Pediatrics

WoS Q Değeri

Q4

Scopus Q Değeri

Q3

Cilt

61

Sayı

4

Künye

Türe, M., Bilici, M., Akın, A., Demir, F., Balık, H. ve Darakçı, S. M. (2019). Complete atrioventricular block associated with clozapine intoxication: case report. Turkish Journal of Pediatrics, 61(4), 618-621.