Genome and metabolome mining of marine obligate salinispora strains to discover new natural products

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dc.authoridGenome and metabolome mining of marine obligate salinispora strains to discover new natural productsen_US
dc.contributor.authorÖzakın, Süleyman
dc.contributor.authorYilmaz, Ebru İnce
dc.date.accessioned2022-02-24T11:36:19Z
dc.date.available2022-02-24T11:36:19Z
dc.date.issued2019en_US
dc.departmentDicle Üniversitesi, Fen Fakültesi, Biyoloji Bölümüen_US
dc.description.abstractMarine microorganisms are receiving more attention as a promising potential source of new natural products. In the present study, we performed genomic and metabolomic analyses to explore the metabolic potential of the obligate marine actinomycete genus Salinispora. The genomes of thirty Salinispora strains were prospected in search of biosynthetic gene clusters including polyketide synthase (PKS), nonribosomal peptide synthetase (NPRS), terpene, indole, lantibiotics, and siderophores. We determined considerable diversity of natural product biosynthetic gene clusters in their genome. There were a total of 1428 putative gene clusters involved in the biosynthesis of various bioactive natural products. Furthermore, 1509 ketosynthase (KS) and condensation (C) domains were detected by using NapDoS belonging to PKS and NRPS genes, respectively. Metabolic profiling was performed by a nontargeted LC-MS/MS approach combined with spectral networking using Global Natural Product Social Molecular Networking (GNPS). Dereplication and tentative identification of natural products were evaluated for common chemical properties and their associated pathways. Significant bioactive natural products such as lomaiviticin C, 7-OH-staurosporine, staurosporine, and cyanosporaside B were determined. More importantly, an unknown glycosylated compound associated with an NRPS/PKS-I hybrid gene cluster in Salinispora pacifica CNY703 was established through chemical and genomic analyses.en_US
dc.identifier.citationÖzakın, S. ve Yilmaz, E. İ. (2019). Genome and metabolome mining of marine obligate salinispora strains to discover new natural products. Turkish Journal of Biology, 43(1), 28-36.en_US
dc.identifier.doi10.3906/biy-1807-136
dc.identifier.endpage36en_US
dc.identifier.issn1300-0152
dc.identifier.issue1en_US
dc.identifier.pmid30930633
dc.identifier.scopus2-s2.0-85062647852
dc.identifier.scopusqualityQ1
dc.identifier.startpage28en_US
dc.identifier.trdizinid336013
dc.identifier.urihttps://pubmed.ncbi.nlm.nih.gov/30930633/
dc.identifier.urihttps://hdl.handle.net/11468/9218
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/336013
dc.identifier.volume43en_US
dc.identifier.wosWOS:000458059900004
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.indekslendigikaynakTR-Dizin
dc.institutionauthorÖzakın, Süleyman
dc.institutionauthorYilmaz, Ebru İnce
dc.language.isoenen_US
dc.publisherScientific and Technical Research Council of Turkeyen_US
dc.relation.ispartofTurkish Journal of Biology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGNPSen_US
dc.subjectSalinisporaen_US
dc.subjectGenome miningen_US
dc.subjectMarine natural productsen_US
dc.subjectMass spectrometryen_US
dc.subjectMetabolomicsen_US
dc.titleGenome and metabolome mining of marine obligate salinispora strains to discover new natural productsen_US
dc.titleGenome and metabolome mining of marine obligate salinispora strains to discover new natural products
dc.typeArticleen_US

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