Effects of nebivolol on ischemia-reperfusion induced testicular injury in a rat testicular torsion model

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dc.authorid0000-0002-2353-1184en_US
dc.contributor.authorTaş, Mahmut
dc.contributor.authorAvinca, Öner
dc.contributor.authorKarakoç, Yenal
dc.contributor.authorDeveci, Engin
dc.date.accessioned2022-12-01T07:47:02Z
dc.date.available2022-12-01T07:47:02Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractOBJECTIVE: To investigate the antioxidant effects of nebivolol in spermatogenic cells against apoptotic and testicular inflammation in torsion-detorsion injury in rats by using TUNEL assay and immunohistochemical methods. STUDY DESIGN: Forty male rats were categorized into 4 groups: control group (abdominal wall was opened and closed), torsion group (left testis was rotated 720 degrees clockwise around longitudinal axis of spermatic cord for 2.5 hours), torsion/detorsion group (after 2.5 hours of torsion process, the suture that fixed the testis to the tunica dartos was cut off for detorsion for the following 3 hours), and torsion/detorsion + nebivolol group (2.5-hour ischemia followed by administration of 10 mg/kg nebivolol 30 minutes prior to a 3-hour torsion/ detorsion). Biochemical assays (MDA, SOD, CAT, GSH) and histopathologic results were examined in the testicular tissue. TUNEL assay method was used for DNA fragmentation analysis in testicular seminiferous tubule sections. RESULTS: Nebivolol treatment seemed to prevent the increase in MDA levels of torsion-detorsion-induced testis. Statistically, SOD, CAT, and GSH activities were significantly decreased in the torsion/detorsion group, while they were increased in the torsion/detorsion + nebivolol group. In the torsion and torsion/detorsion groups, an increase in apoptosis was observed in the germ cells in the tubules, and it was seen that the application of nebivolol decreased germ cell apoptosis. CONCLUSION: Unilateral testicular torsion-detorsion causes testicular damage to the ipsilateral testis as evidenced by biochemical and apoptotic changes in the tissues and retains the morphological structure in the testes after nebivolol administration, after testicular torsion-detorsion damage, and decreased apoptotic index and inflammation.en_US
dc.identifier.citationTaş, M., Avinca, Ö., Karakoç, Y. ve Deveci, E. (2021). Effects of nebivolol on ischemia-reperfusion induced testicular injury in a rat testicular torsion model. Analytical and Quantitave Cytopathology and Histopathology, 43(2), 52-58.en_US
dc.identifier.endpage58en_US
dc.identifier.issn0884-6812
dc.identifier.issue2en_US
dc.identifier.startpage52en_US
dc.identifier.urihttps://hdl.handle.net/11468/10917
dc.identifier.volume43en_US
dc.identifier.wosWOS:000664044000003
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.institutionauthorDeveci, Engin
dc.language.isoenen_US
dc.publisherSCI Printers & Publication INCen_US
dc.relation.ispartofAnalytical and Quantitave Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDetorsionen_US
dc.subjectIschemia-reperfusion injuryen_US
dc.subjectNebivololen_US
dc.subjectOxidative stressen_US
dc.subjectRatsen_US
dc.subjectWistaren_US
dc.subjectReperfusion injuryen_US
dc.subjectSpermatic cord torsionen_US
dc.subjectSpermatogenesisen_US
dc.subjectTesticular torsionen_US
dc.subjectTestisen_US
dc.subjectTorsion abnormalityen_US
dc.subjectTorsion-detorsionen_US
dc.titleEffects of nebivolol on ischemia-reperfusion induced testicular injury in a rat testicular torsion modelen_US
dc.titleEffects of nebivolol on ischemia-reperfusion induced testicular injury in a rat testicular torsion model
dc.typeArticleen_US

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