THE POTENTIAL BENEFICIAL EFFECTS OF ETHYL PYRUVATE ON DIABETIC NEPHROPATHY: AN EXPERIMENTAL AND ULTRASTRUCTURAL STUDY

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dc.contributor.authorBahadir, Mehmet Veysi
dc.contributor.authorYildirim, Yasar
dc.contributor.authorBaran, Ozlem Pamukcu
dc.contributor.authorPolat, Sait
dc.contributor.authorAkkoc, Hasan
dc.contributor.authorTunik, Selcuk
dc.date.accessioned2024-04-24T17:24:53Z
dc.date.available2024-04-24T17:24:53Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractOxidative stress is one of the main causes of diabetic nephropathy, which is a complication of diabetes mellitus (DM). The aim of this study was to investigate the possible role of ethyl pyruvate (EP) in streptozotocin-induced diabetic rats' kidney. Four groups (n = 8) of male Wistar albino rats were used as follows: control group rats received only sodium citrate buffer solution intraperitoneally (ip). The EP group was given 50 mg/kg EP ip. In the DM group, diabetes was induced by streptozotocin. The DM + EP group received 50 mg/kg EP ip. All animals received daily treatment for 14 days, and at the end of the study the kidneys were removed: the left kidney of the rats was used for malondialdehyde (MDA) analysis and the right kidney for histological examination. There was normal appearance of the kidney tissues in the control and the EP-administered groups. In the DM group, there was evident basement membrane thickening and enlargement of mesangial matrix; swelling in some tubular epithelial cells was also noticeable. In the DM+EP administered group, nearly the same appearance as the control group and relative thickening in the glomerular basal membrane were observed. The antioxidant effect of ethyl pyruvate improved the renal structures in the DM + EP group.en_US
dc.identifier.doi10.5114/PJP.2016.63777
dc.identifier.endpage257en_US
dc.identifier.issn1233-9687
dc.identifier.issue3en_US
dc.identifier.pmid28155974
dc.identifier.scopus2-s2.0-84997496851
dc.identifier.scopusqualityQ4
dc.identifier.startpage250en_US
dc.identifier.urihttps://doi.org/10.5114/PJP.2016.63777
dc.identifier.urihttps://hdl.handle.net/11468/19870
dc.identifier.volume67en_US
dc.identifier.wosWOS:000389170800009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherVesalius Univ Medical Publen_US
dc.relation.ispartofPolish Journal of Pathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEthyl Pyruvateen_US
dc.subjectDiabetes Mellitusen_US
dc.subjectNephropathyen_US
dc.subjectStreptozotocinen_US
dc.titleTHE POTENTIAL BENEFICIAL EFFECTS OF ETHYL PYRUVATE ON DIABETIC NEPHROPATHY: AN EXPERIMENTAL AND ULTRASTRUCTURAL STUDYen_US
dc.titleTHE POTENTIAL BENEFICIAL EFFECTS OF ETHYL PYRUVATE ON DIABETIC NEPHROPATHY: AN EXPERIMENTAL AND ULTRASTRUCTURAL STUDY
dc.typeArticleen_US

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