New voltammetric approach to the quantitative estimation of sildenafil citrate in tablets using disposable pencil graphite electrode
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Tarih
2014
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
American Scientific Publishers
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The voltammetric behavior of sildenafil citrate (SC) was studied through differential pulse stripping voltammetry. The best sensitivity, optimal experimental conditions and settings for the voltammetric method development were obtained by applying experimental design and optimization methodology to the designed sample runs at different accumulation times, accumulation potentials and pHs. The linearity over the concentration range 1 × 10-7 M-8 × 10-6 M for SC was determined and the limit of detection (LOD) was 3.1 × 10-8 M. For the method ability and validity, mean recovery result and relative standard deviation were found to be 99.3% and 2.19%, respectively. The method was applied to the determination of SC in pharmaceutical and plasma samples.
Açıklama
Anahtar Kelimeler
Differential pulse stripping voltammetric determination, Experimental design and optimization, Pencil graphite electrode, Plasma samples, Sildenafil citrate
Kaynak
Sensor Letters
WoS Q Değeri
Scopus Q Değeri
N/A
Cilt
12
Sayı
11
Künye
Güzel, R., Ekşi, H., Dinç, E. ve Solak, A. O. (2014). New voltammetric approach to the quantitative estimation of sildenafil citrate in tablets using disposable pencil graphite electrode. Sensor Letters, 12(11), 1675-1681.
