The Effect of interleukin 23 levels on clinical and paboratory parameters of patients with ankylosing spondylitis

Basit Öğe Kaydı
dc.contributor.authorElbey, B.
dc.contributor.authorAyyıldız, O.
dc.contributor.authorYazgan, U. C.
dc.contributor.authorÇevik, R.
dc.contributor.authorKaplan, I.
dc.contributor.authorSarıyıldız, M. A.
dc.date.accessioned2022-12-21T12:42:47Z
dc.date.available2022-12-21T12:42:47Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, İmmünoloji Ana Bilim Dalıen_US
dc.description.abstractObjective: In the present study, we aimed to investigate the relationship between interleukin 23 (IL-23) and the clinical and laboratory parameters in patients with ankylosing spondylitis (AS). Ankylosing spondylitis causes structural and functional inability, particularly in the axial skeleton, and results in the inflammatory lower back pain. At the same time, we aimed to investigate the relationship between IL-23 levels and disease related variables in patients with AS. Methods: A total of 38 patients with AS (33 males and 5 females) and 42 healthy controls (32 males and 10 female) were enrolled in the study. The demographic characteristics of the participants were recorded. As laboratory findings, erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), and IL-23 values were noted. Bath AS Disease Activity Index, Bath AS Functional Index, Visual Analogue Scale, and AS Quality of Life scales of the patients were measured. Results: The mean age of the AS group and the control subjects was 32.4 +/- 7.06 and 30.0 +/- 6.24 years, respectively. The ESR, CRP and IL-23 levels were significantly higher in the AS group compared to those of the healthy controls (p < 0.001, p < 0.013, p < 0.012, respectively). There was a significant correlation between ESR, CRP, and IL-23 levels in patients with AS (r = 0.328, p = 0.030 and r = 0.392, p = 0.008, respectively). While 12 subjects (31.5%) were positive for peripheral arthritis, 26 patients were negative (68.4%). The IL-23 levels were significantly higher in the group that was positive for peripheral arthritis (p < 0.05). Conclusion: Interleukin 23 may play a role in the progression and/or pathogenesis of AS and is most likely involved in the joint problems independent of the classic inflammatory response measures.en_US
dc.identifier.citationElbey, B., Ayyıldız, O., Yazgan, U. C., Çevik, R., Kaplan, I., Sarıyıldız, M.A. (2021). The Effect of interleukin 23 levels on clinical and paboratory parameters of patients with ankylosing spondylitis. West Indian Medical Journal, 69(4), 222-226.en_US
dc.identifier.doi10.7727/wimj.2015.241
dc.identifier.endpage226en_US
dc.identifier.issn0043-3144
dc.identifier.issn2309-5830
dc.identifier.issue4en_US
dc.identifier.scopus2-s2.0-85122105569
dc.identifier.scopusqualityQ4
dc.identifier.startpage222en_US
dc.identifier.urihttps://www.mona.uwi.edu/fms/wimj/article/2581
dc.identifier.urihttps://hdl.handle.net/11468/11099
dc.identifier.volume69en_US
dc.identifier.wosWOS:000719637900009
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorElbey, B.
dc.institutionauthorAyyıldız, O.
dc.institutionauthorYazgan, U.C.
dc.institutionauthorÇevik, R.
dc.institutionauthorKaplan, I.
dc.institutionauthorSarıyıldız, M.A.
dc.language.isoenen_US
dc.publisherUniv West Indies Faculty Medical Sciencesen_US
dc.relation.ispartofWest Indian Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnkylosing spondylitisen_US
dc.subjectC-reactive proteinen_US
dc.subjectInterleukin 23en_US
dc.subjectDisease activityen_US
dc.titleThe Effect of interleukin 23 levels on clinical and paboratory parameters of patients with ankylosing spondylitisen_US
dc.titleThe Effect of interleukin 23 levels on clinical and paboratory parameters of patients with ankylosing spondylitis
dc.typeArticleen_US

Dosyalar

Orijinal paket
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
The Effect of interleukin 23 levels on clinical and paboratory parameters of patients with ankylosing spondylitis.pdf
Boyut:
337.31 KB
Biçim:
Adobe Portable Document Format
Açıklama:
Makale Dosyası
İndir
Lisans paketi
Listeleniyor 1 - 1 / 1
[ X ]
İsim:
license.txt
Boyut:
1.44 KB
Biçim:
Item-specific license agreed upon to submission
Açıklama:
İndir

Koleksiyon

Temel Tıp Bilimleri Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu