Syndromic craniosynostosis: A review

Craniosynostosisis a defect of the skull caused by premature fusion of one or more cranial sutures. It may be isolated finding or part of a syndrome and affects 1 in every 2,500 live births.Usually multiple sutures are involved and correspond in at least 20% of the cases. Syndromic craniosynostosis can be associated with various dysmorphic features involving the face, skeleton and nervous system. More than 180 syndromes have been reported with craniosynostosis.The aim of this review is to present the clinical and genetic characteristics of the most common types of syndromiccraniosynostosis.