Role of 68Ga-PSMA PET/CT parameters in treatment evaluation and survival prediction in prostate cancer patients compared with biochemical response assessment
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Tarih
2021
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Hellenic Soc Nuclear Medicine
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Objective: In this study, we aimed to evaluate the concordance of biochemical treatment response with gallium-68-prostate specific membrane antigen (Ga-68-PSMA) positron emission tomography/computed tomography (PET/CT) treatment response in prostate cancer (PCa) and investigate their prognostic effects on survival. Materials and Methods: One hundred and fifty-one patients with PCa, who underwent Ga-68-PSMA PET/CT imaging in our clinic between May 2016 and December 2019, were on treatment, and had pre-treatment and post-treatment imaging studies were included in our study. The treatment patients received and prostate-specific antigen (PSA) levels at the time of PET/CT imaging were recorded. Pre- and post-treatment whole-body metabolic tumor volume (MTVw), whole-body total lesion PSMA (TLPw), percent change in PSA (Delta PSA), Delta MTV, and Delta TLP values were calculated in all patients. Survival time of all patients was measured from the time of initial PET imaging. Results: Median age of patients included in our study was 71 years (range: 51-88). When Delta PSA response and Delta TLP response were evaluated together (r:0.71, P<0.001 and k:0.541, P<0.001), statistically significance strong correlation and moderate concordance was observed. Delta PSA response and Delta MTV treatment response had statistically significant moderate correlation and moderate concordance (r: 0.66, P<0.01 and k: 0.454, P<0.001, significantly). Between Delta PSA response and Delta TLP and Delta MTV response had stronger correlation and higher concordance when PSA levels were above 10. Multivariate analyses using multiple Cox regression analysis revealed MTVw1 and Delta MTV parameters to be independent prognostic factors for mortality (P:0.003 and P:0.001, respectively). Conclusion: We observed that biochemical response and whole-body volumetric Ga-68-PSMA PET/CT parameter response showed correlation and concordance in all groups with PCa, which was more significant when PSA level was >= 10ng/mL. MTVw1 and Delta MTV parameters obtained via Ga-68-PSMA PET/CT were independent prognostic factors for mortality in Pca. Gallium-68-PSMA PET/CT is a valuable imaging technique for diagnostic purposes as well as follow-up and prognostic evaluation.
Açıklama
Anahtar Kelimeler
Prostate Cancer, Psa, Psma, Whole-Body Mtv, Total Lesion Psma
Kaynak
Hellenic Journal of Nuclear Medicine
WoS Q Değeri
Q4
Scopus Q Değeri
Cilt
24
Sayı
1
