Expression of endothelin-1 and Ki-67 in normotensive and severe preeclamptic placentas

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dc.authorid0000-0002-0547-4139en_US
dc.authorid0000-0002-3280-1430en_US
dc.authorid0000-0002-2325-7277en_US
dc.authorid0000-0002-2353-1184en_US
dc.contributor.authorEkinci, Aysun
dc.contributor.authorAktaş, Ayfer
dc.contributor.authorDönder, Ahmet
dc.contributor.authorEkinci, Cenap
dc.contributor.authorTurgut, Abdulkadir
dc.contributor.authorDeveci, Şenay
dc.contributor.authorDeveci, Engin
dc.date.accessioned2022-12-12T06:49:47Z
dc.date.available2022-12-12T06:49:47Z
dc.date.issued2018en_US
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Tıbbi Biyokimya Ana Bilim Dalıen_US
dc.description.abstractSevere preeclampsia (HELLP syndrome) is a life-threatening pregnancy complication, usually a severe form of preeclampsia. In this study, we aimed to examine histopathologic changes and Endothelin-1 and KI-67 expression levels by immunohistochemical methods in severe preeclamptic placentas. Severe preeclampsia and obstetric characteristics and biochemical and hematological characteristics of healthy subjects were compared. Placenta sections were stained with hematoxylin-eosin for histopathological examination. In the histopathological examination of severe preeclamptic placenta, degeneration in synaptic and cytotrophoblastic cells, increase in insidious knots, fibrinoid necrosis, degeneration in endothelial cells, calcification and hyaline villous stains were observed. In the severe preeclampsia group, Ki-67 expression increased in decidua cells and inflammatory cells, while endothelial cells in the vessel wall and inflammatory cells in the villus and intervillous spaces increased. It is thought that angiogenetic and cellular proliferation is induced in a co-ordinated manner and significantly influences fetal development.en_US
dc.identifier.citationEkinci, A., Aktaş, A., Dönder, A., Ekinci, C., Turgut, A. ve Deveci, Ş. (2018). Expression of endothelin-1 and Ki-67 in normotensive and severe preeclamptic placentas. International Journal of Morphology, 36(1), 109-112.en_US
dc.identifier.doi10.4067/S0717-95022018000100109en_US
dc.identifier.endpage112en_US
dc.identifier.issn0717-9367
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85044584752en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage109en_US
dc.identifier.urihttps://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022018000100109&lng=en&nrm=iso&tlng=en
dc.identifier.urihttps://hdl.handle.net/11468/11020
dc.identifier.volume36en_US
dc.identifier.wosWOS:000438813400019
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.institutionauthorEkinci, Aysun
dc.institutionauthorAktaş, Ayfer
dc.institutionauthorDönder, Ahmet
dc.institutionauthorEkinci, Cenap
dc.institutionauthorDeveci, Şenay
dc.institutionauthorDeveci, Engin
dc.language.isoenen_US
dc.publisherUniversidad de la Fronteraen_US
dc.relation.ispartofInternational Journal of Morphologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectHellp syndromeen_US
dc.subjectPlacentaen_US
dc.subjectKi-67 antibodyen_US
dc.subjectEndothelin-1en_US
dc.titleExpression of endothelin-1 and Ki-67 in normotensive and severe preeclamptic placentasen_US
dc.title.alternativeExpresión de endotelina-1 y Ki-67 en placentas normotensas y preeclampsia severaen_US
dc.typeArticleen_US

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