Unravelling the phenolic compound reserves, antioxidant and enzyme inhibitory activities of an endemic plant species, Achillea pseudoaleppica

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dc.authorid0000-0002-4090-7227en_US
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorTaslimi, Parham
dc.contributor.authorKılıç, Ömer
dc.contributor.authorGülçin, İlhami
dc.contributor.authorDey, Abhijit
dc.contributor.authorBursal, Ercan
dc.date.accessioned2023-01-03T07:10:59Z
dc.date.available2023-01-03T07:10:59Z
dc.date.issued2021en_US
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümüen_US
dc.description.abstractThe present ethnobotanical study unravelled the phenolic reservoir (UHPLC-MS/TQ-MS) and pharmacological activity (antioxidant and enzyme inhibitory activities) of an endemic plant, Achillea pseudoaleppica Hub.-Mor. (Asteraceae). The effective antioxidant properties of ethanol and water extracts of A. pseudoaleppica leaves were determined by using six different in vitro bioanalytical methods including three reducing antioxidant methods and three radical scavenging antioxidant methods. In the other step of the study, the enzyme inhibitory effects of water and ethanol extracts of A. pseudoaleppica were determined against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), alpha-amylase, and alpha-glucosidase enzymes. The ethanol extract was found to have effective inhibition potential for all four respected enzymes. The IC50 values of A. pseudoaleppica extract against AChE, BChE, alpha-amylase, and alpha-glucosidase enzymes were found to be 2.67 mg/mL, 4.55 mg/mL, 16.51 mg/mL, and 12.37 mg/mL, respectively. Also, UHPLC-MS/TQ-MS analyses revealed quinic acid as the most abundant phenolic compound of the water extract (31.12 +/- 1.65 mu g/mg) and ethanol extract (11.75 +/- 0.82 mu g/mg). In addition, the molecular docking interaction of the most abundant phenolic compound of A. pseudoaleppica (quinic acid) with AChE, BChE, alpha-amylase, and alpha-glucosidase target enzymes were evaluated using Chimera and AutoDock Vina softwares. In conclusion, the rich phenolic content and the potent antioxidant and enzyme inhibitory properties of A. pseudoaleppica extracts may support the widespread ethnobotanical use of the plant application. Communicated by Ramaswamy H. Sarmaen_US
dc.identifier.citationYılmaz, M.A., Taslimi, P., Kılıç, Ö., Gülçin, İ., Dey, A., Bursal, E. (2021). Unravelling the phenolic compound reserves, antioxidant and enzyme inhibitory activities of an endemic plant species, Achillea pseudoaleppica. Journal of Biomolecular Structure & Dynamics, Early Access.en_US
dc.identifier.doi10.1080/07391102.2021.2007792
dc.identifier.issn0739-1102
dc.identifier.issn1538-0254
dc.identifier.pmid34822320
dc.identifier.scopus2-s2.0-85120675758
dc.identifier.scopusqualityQ1
dc.identifier.urihttps://www.tandfonline.com/doi/full/10.1080/07391102.2021.2007792
dc.identifier.urihttps://hdl.handle.net/11468/11176
dc.identifier.volumeEarly Accessen_US
dc.identifier.wosWOS:000722538900001
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.language.isoenen_US
dc.publisherTaylor & Francisen_US
dc.relation.ispartofJournal of Biomolecular Structure & Dynamics
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAchillea pseudoaleppicaen_US
dc.subjectAntioxidanten_US
dc.subjectEnzyme inhibitionen_US
dc.subjectPhenolic contenten_US
dc.subjectRadical scavengingen_US
dc.titleUnravelling the phenolic compound reserves, antioxidant and enzyme inhibitory activities of an endemic plant species, Achillea pseudoaleppicaen_US
dc.titleUnravelling the phenolic compound reserves, antioxidant and enzyme inhibitory activities of an endemic plant species, Achillea pseudoaleppica
dc.typeArticleen_US

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