Effect of Rutin on Pulmonary Injury in Everolimus-Administered Rats Biochemical and Histopathological Evaluation

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dc.authoridMokhtare, Behzad/0000-0002-9075-7239
dc.authoridDemir, Omer Faruk/0000-0001-8380-9312
dc.contributor.authorDemir, Omer Faruk
dc.contributor.authorSuleyman, Zeynep
dc.contributor.authorSuleyman, Halis
dc.contributor.authorCoban, Taha Abdulkadir
dc.contributor.authorMokhtare, Behzad
dc.date.accessioned2025-02-22T14:08:39Z
dc.date.available2025-02-22T14:08:39Z
dc.date.issued2024
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackground and Objective: Everolimus is an anticancer agent that inhibits the Mammalian Target of Rapamycin (mTOR). It causes side effect such as pneumonia. This study aimed to evaluate rutin's effect on potential pulmonary injury in everolimus-administered rats biochemically and histopathologically. Materials and Methods: All rats were split into: Healthy (HG), everolimus-treated (EVR) (2 mg/kg) and rutin (50 mg/kg)+everolimus-treated (REV). Rutin was administered to the REV group and physiological saline was given orally tothe EVR and HG groups. As 1 hr later, everolimus 2 mg/kg was administered to REV and EVR groups. The process was repeated daily, 4 times weekly. Then, high dose anaesthesia was used to kill the rats and lung tissue samples were extracted. Oxidative stress and pro-inflammatory cytokine markers were examined and ANOVA test was applied. Results: Oxidative and inflammatory lung damage developed in the everolimus-treated rats. Rutin attenuated this oxidative and pro-inflammatory lung damage induced by everolimus. Rats administered with everolimus developed severe interstitial pneumonia, lymphoid hyperplasia and desquamation in lung tissues. This severe damage was reduced to mild level by administering rutin. Conclusion: The adding rutin to the treatment regimen for pulmonary damage associated with everolimus may have a preventive impact.en_US
dc.identifier.doi10.3923/ijp.2024.1000.1007
dc.identifier.issn1811-7775
dc.identifier.issn1812-5700
dc.identifier.issue6en_US
dc.identifier.urihttps://doi.org/10.3923/ijp.2024.1000.1007
dc.identifier.urihttps://hdl.handle.net/11468/29538
dc.identifier.volume20en_US
dc.identifier.wosWOS:001337978400010
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherAsian Network Scientific Information-Ansineten_US
dc.relation.ispartofInternational Journal of Pharmacologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subjectEverolimusen_US
dc.subjectoxidative stressen_US
dc.subjectrutinen_US
dc.subjectpro-inflammatoryen_US
dc.subjectpulmonary damageen_US
dc.subjectraten_US
dc.titleEffect of Rutin on Pulmonary Injury in Everolimus-Administered Rats Biochemical and Histopathological Evaluationen_US
dc.typeArticleen_US

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