Growth hormone stimulation tests in chronic renal failure with metabolic acidosis
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Tarih
1998
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Blackwell Publishing Asia
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Metabolic acidosis is one of the possible causes of growth retardation in chronic renal failure (CRF). Data about the effect of metabolic acidosis on growth hormone (GPI) secretion in CRF are limited. A study was carried out on eight CRF patients, hospitalized because of severe metabolic acidosis, and eight age-matched prepubertal healthy short children. Growth hormone stimulation tests were done with L-dopa and clonidine before or during acidosis therapy and after the correction of metabolic acidosis. The levels of GH were measured by radio-immunoassay. The mean of the peaks of both tests were used for each patient and statistical significance was tested by Mann-Whitney U and Wilcoxon tests. No difference was found between the GH peaks of the two groups during acidosis and after the correction of acidosis (Wilcoxon test, P > 0.05). In view of this data it was concluded that metabolic acidosis has little effect on GH stimulation tests.
Açıklama
Anahtar Kelimeler
Chronic Renal Failure, Growth Hormone, Metabolic Acidosis
Kaynak
Acta Paediatrica Japonica
WoS Q Değeri
Q4
Scopus Q Değeri
N/A
Cilt
40
Sayı
1
