The computational and biological investigation of indole and quinoline based thiosemicarbazones towards ?-glucosidase enzyme inhibition
Yükleniyor...
Dosyalar
Tarih
2022
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Gaziantep University
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Thiosemicarbazones are important classes of Schiff base ligands due to the presence of conjugated N-N-S system providing an important therapeutic potential and have been the subject of many structural and medicinal studies via the interactions of biomolecules. A wide variety of heterocyclic systems have been used for the structural modifications of new thiosemicarbazone based compounds. Due to the presence of the indole and quinoline structures in many natural products, studies have been directed towards investigations of the biological properties of natural indolic and quinolic compounds, and a range of medical uses has been identified.
In the present work, the synthetic procedures and chemical characterization of the targeted compounds derived from indole-3-carbaldehyde and 2-chloroquinoline-3-carbaldehyde systems with a range of thiosemicarbazides. The final compounds have been subjected to α-glucosidase enzyme inhibition assay to investigate the antidiabetic efficiency. A complementary study was carried out with the molecular docking study of targeted compounds on the catalytic side of the designated enzyme. The biological aspect of the study revealed that the indole-based compounds possessed more promising potency compared to the quinoline derivatives.
Açıklama
Anahtar Kelimeler
Indole, Quinoline, Thiosemicarbazone, α-glucosidase, Diabetes
Kaynak
The Sixth International Symposium on Pharmaceutical and Biomedical Sciences
WoS Q Değeri
Scopus Q Değeri
Cilt
Sayı
Künye
Bingül, M. ve Şahin, H. (2022). The computational and biological investigation of indole and quinoline based thiosemicarbazones towards α-glucosidase enzyme inhibition. The Sixth International Symposium on Pharmaceutical and Biomedical Sciences,26-28 Mayıs 2022 içinde. (pp. 140-147). Gaziantep: Gaziantep University
