Protective effects of melatonin on doxorubicin induced cardiotoxicity in isolated rat heart

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dc.contributor.authorErdinç, Meral
dc.contributor.authorAkkoç, Hasan
dc.contributor.authorKelle, İlker
dc.contributor.authorErdoğmuş, Zeynep Ozgen
dc.date.accessioned2024-04-24T19:07:46Z
dc.date.available2024-04-24T19:07:46Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractDoxorubicin is a highly effective cancer chemotherapeutic agent and its clinical use is limited by its serious cardiotoxicity. Oxidative damage is suggested to play a major role in its cardiotoxicity. In this study we aimed to research the protective effects of melatonin-which is a free radical scavenger and antioxidant -on Doxorubicin-induced cardiotoxicity in isolated perfused rat heart. Male wistar albino rats were divided into four groups: 1.group: control (1ml (i.p) sterile saline), 2.group: Doxorubicin (Dox) (one dose, 10 mg/kg (i.p)), 3.group: Dox (one dose, 10 mg/kg (i.p)) + Melatonin (Mel) for 7 days once a day 10 mg/kg (i.p)), 4.group: Melatonin (for 7 days once a day 10 mg/kg (i.p)). After 7 days, the hearts were isolated and perfused by Langendorff system. Heart rate, coronary perfusion pressure, Left ventricular developed pressure (LVDP), LV (dP/dt)max and LV(dP/dt)min which shows max and min pressures during systole and diastole per time were recorded. As a result; a significant increase in coronary perfusion pressure and LV(dP/dt)min and also a significant decrease in LVDP, LV(dP/dt)max and heart rates in the Dox group according to control group showed altered cardiac functions induced by Dox. versus the Dox group, in the Dox+Mel group the coronary perfusion pressure and LV(dP/dt)min significantly decreased and LVDP and LV(dP/dt)max significantly increased. So it is concluded that melatonin has protective effects on doxorubicin induced cardiotoxicity characterized with altered heart contractility and hemodynamics.en_US
dc.identifier.endpage124en_US
dc.identifier.issn1301-0883
dc.identifier.issn1339-3886
dc.identifier.issue3en_US
dc.identifier.startpage119en_US
dc.identifier.trdizinid255691
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/255691
dc.identifier.urihttps://hdl.handle.net/11468/27597
dc.identifier.volume21en_US
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.relation.ispartofEastern Journal of Medicine
dc.relation.publicationcategoryMakale - Ulusal Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleProtective effects of melatonin on doxorubicin induced cardiotoxicity in isolated rat hearten_US
dc.titleProtective effects of melatonin on doxorubicin induced cardiotoxicity in isolated rat heart
dc.typeArticleen_US

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