The association between depression and vitamin D and parathyroid hormone levels in adolescents
Yükleniyor...
Tarih
2016
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Mashhad University of Medical Sciences
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: Depression, a challenging disorder, affects 1–6% of adolescents and early onset often
predicts more serious manifestations in later life. Elevated Parathyroid hormone (PTH), parathormone
levels have reported among adults with depression. In this study, the roles of 25(OH) D (vitamin D)
and parathormone during adolescence, in which the frequency of depression is high, were studied.
Materials and Methods:
Patients who were followed-up jointly at both clinics and whose 25(OH) D and PTH levels were
evaluated and questioned "Depression Scale for Children" for depression at the same time, were
included in the study. Cases’ socio-demographic data, 25(OH) D and PTH levels and Depression
Scale’ scores were recorded.
Results: Depression was diagnosed in 35 (25.3%) of the 138 patients. No differences were found
between vitamin D and parathormone in terms of age and gender in groups either with or without
depression. Negative correlation was found between the vitamin D levels and depression score in the
group with depression (r=-0.368; P=0.03). A significant and positive correlation was found between
the PTH levels and depression score (r=0.399; P=0.018). A significant and negative correlation was
found between 25(OH) D and PTH levels.
Conclusion:
Even if clinical depression is absent, the frequency of depressive symptoms is increased with
decreased vitamin D levels and increased PTH levels, independent of other factors. The prevention of
depression, specifically in adolescents, is important to decrease possible suicidal and homicidal
thoughts that might arise during adulthood, and substance abuse. Maintaining vitamin D support
during adolescence, as with the first year of life, is necessary for both the prevention and treatment of
depression.
Açıklama
Anahtar Kelimeler
Adolescents, Depression, Vitamin D, Parathormone, Prevention
Kaynak
International Journal of Pediatrics
WoS Q Değeri
N/A
Scopus Q Değeri
N/A
Cilt
4
Sayı
2
Künye
Karabel, M., Şimşek, Ş., Haspolat, Y. K., Kelekçi, S., Karabel, D., Tuncel, T. ve diğarleri. (2016). The association between depression and vitamin D and parathyroid hormone levels in adolescents. International Journal of Pediatrics, 4(2), 1365-1372.
