Temperature behaviour studies on antipsychotic drug Olanzapine
Yükleniyor...
Tarih
2017
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Bv
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The antipsychotic drug Olanzapine in powder form was Co-60 gamma irradiated to investigate in various temperature value. The Electron Paramagnetic Resonance (EPR) spectrum of the irradiated Olanzapine, characterized by g = 2.0030, exhibits an intensity distribution 1:2:1. The room temperature EPR spectra of gamma irradiated Olanzapine was recorded in DMSO solution at frozen state. Temperature behavior of Olanzapine discussed by means of similarities and differences of EPR parameters. Kinetic decay features of radicals induced by gamma irradiation of Olanzapine were also studied. EPR experiments indicated that Olanzapine contained stable free radical species after irradiation and the intensity of the signal is increasing with the absorbed doses suggesting increasing radical concentration in the system. (C) 2017 Elsevier B.V. All rights reserved.
Açıklama
Anahtar Kelimeler
Antipsychotic drug, Epr, Gamma irradiation, Kinetics
Kaynak
Journal of Molecular Structure
WoS Q Değeri
Q3
Scopus Q Değeri
Q1
Cilt
1149
Sayı
Künye
Erdamar, I. Y. D. (2017). Temperature behaviour studies on antipsychotic drug Olanzapine. Journal of Molecular Structure, 1149, 196-198.
