Phenolic Profile, Fatty Acid and Essential Oil Composition Analysis and Antioxidant, Antialzheimer and Antibacterial Activities of Verbascum flavidum Extracts

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dc.contributor.authorBoga, Mehmet
dc.contributor.authorErtas, Abdulselam
dc.contributor.authorHasimi, Nesrin
dc.contributor.authorDemirci, Serpil
dc.contributor.authorYilmaz, Mustafa Abdullah
dc.contributor.authorTemel, Hamdi
dc.contributor.authorKolak, Ufuk
dc.date.accessioned2024-04-24T17:37:45Z
dc.date.available2024-04-24T17:37:45Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractThis paper is the first report about phytochemical analysis with LC-MS/MS and biological activities of Verbascum flavidum (Boiss.) Freyn & Bornm. Rutin (1077.09 +/- 77.47 mu g analyte/g extract) and chlorogenic acid (1012.42 +/- 97.18 mu g analyte/g extract) were determined as the most abundant phenolics in V. flavidum. The main components of fatty acid were found to be palmitic (30.3%) and oleic acids (17.9%); while the major essential oils were determined as arachidic acid (16.4%) and alpha-selinene (8.9%) by GC-MS analysis. In DPPH free radical scavenging activity the methanol extract showed higher activity than BHT with 72.62% inhibition at 100 mu g/mL concentration. The methanol and water extracts of V. flavidum showed 86.01 and 87.39 % inhibition in ABTS cation radical scavenging assay at 100 mu g/mL concentration, respectively. The methanol extract showed moderate activity against E. coli with 250 +/- 0.3 MIC value and with 15 mm inhibition zone diameter at 30 mg/mL concentration.en_US
dc.description.sponsorshipDicle University Science and Technology Research and Application Center (DUBTAM)en_US
dc.description.sponsorshipThanks to the Dicle University Science and Technology Research and Application Center (DUBTAM) for the partial support of this study.en_US
dc.identifier.endpage1100en_US
dc.identifier.issn0125-2526
dc.identifier.issue5en_US
dc.identifier.scopus2-s2.0-84992143208
dc.identifier.scopusqualityQ3
dc.identifier.startpage1089en_US
dc.identifier.urihttps://hdl.handle.net/11468/21161
dc.identifier.volume43en_US
dc.identifier.wosWOS:000390179600016
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherChiang Mai Univen_US
dc.relation.ispartofChiang Mai Journal of Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectVerbascum Flavidumen_US
dc.subjectAntioxidanten_US
dc.subjectAnticholinesteraseen_US
dc.subjectAntimicrobialen_US
dc.subjectLc-Ms/Msen_US
dc.subjectGc-Msen_US
dc.titlePhenolic Profile, Fatty Acid and Essential Oil Composition Analysis and Antioxidant, Antialzheimer and Antibacterial Activities of Verbascum flavidum Extractsen_US
dc.titlePhenolic Profile, Fatty Acid and Essential Oil Composition Analysis and Antioxidant, Antialzheimer and Antibacterial Activities of Verbascum flavidum Extracts
dc.typeArticleen_US

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