A retrospective evaluation of geriatric patients with gastric cancer receiving systemic chemotherapy
Yükleniyor...
Tarih
2020
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wolters Kluwer Medknow Publications
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Background: The most common age at which gastric cancer is diagnosed is 70 years, and the majority of patients diagnosed are
at the metastatic stage. However, although gastric cancer is a geriatric disease, there is no suggestion to discriminate treatment
for the general geriatric patient population. Here, we evaluated patients receiving palliative chemotherapy for gastric cancer owing
to advanced age.
Patients and Methods: Multicenter data of geriatric patients receiving palliative chemotherapy because of metastatic gastric cancer
were retrospectively reviewed.
Results: In total, 262 geriatric patients with gastric cancer were included in the study. Of these, 167 patients, including 134 (51.8%)
patients with metastasis at diagnosis and 33 patients with relapse after surgery, were evaluated for palliative therapy. Chemotherapy
was started in 87 (52.1%) of 167 patients. The overall median survival of the patients receiving chemotherapy was 9.3 months.
There was no difference in overall survival (OS) between patients aged >70 and <70 years. However, a significant difference was
detected in OS of patients depending on their Eastern Cooperative Oncology Group (ECOG) performance status(PS) before treatment;
survival was 15 months in the group with PS 0–1 and 7 months in the group with PS ≥2.
Conclusion: Advanced age chemotherapy receiving rates in patients with metastatic gastric cancer is decreasing. Survival is not
associated with age, but pretreatment ECOG PS is important. Therefore, ECOG PS and comorbidities should be evaluated in detail,
and combination therapies could contribute to patient survival.
Açıklama
PMID: 33380668
WOS:000612861200024
WOS:000612861200024
Anahtar Kelimeler
Geriatric patients, Metastatic gastric cancer, Systemic chemotherapy
Kaynak
Journal of Cancer Research and Therapeutics
WoS Q Değeri
Q4
Scopus Q Değeri
Q3
Cilt
16
Sayı
8
Künye
Tatlı, A. M., Urakçı, Z., Taştekin, D., Koca, D., Göksu, S. S., Üyetürk, Ü. ve diğerleri. (2020). A retrospective evaluation of geriatric patients with gastric cancer receiving systemic chemotherapy. Journal of Cancer Research and Therapeutics, 16(8), 138-143.
