The effects of the nitric oxide donor molsidomine prevent in warm ischemia-reperfusion injury of the rat renal - A functional and histopathological study
Yükleniyor...
Tarih
2001
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim of this experimental study is to verify the protective effect of molsidomine on the renal function and structural modifications in the ischemia-reperfusion rat kidney. Sixty-eight male Sprague-Dawley rats, which were right nephrectomized and occluded left renal artery for 60 minutes were used. Group I (n = 10) sham-operated animals, which only underwent right nephrectomy. Group II (n = 20) Untreated ischemic rats, which underwent left renal ischemia by occlusion of the renal artery for 60 minutes before blood was restored. Group III (n = 18) molsidomine treated ischemic rats, Group IV (n = 20) L-NAME (NG-nitro-L-arginine methyl ester) treated ischemic rats. Serum creatinine and blood urea nitrogen (BUN) were measured daily and biopsies were obtained from the remaining left kidneys. At seventh day, 55% and 50% of the rats remained alive at the G-II and G-IV respectively. Molsidomine treated rats (G-III) were alive and healthy at day 7. The serum creatinine and BUN levels were significantly higher in G-II and G-IV when compared with the sham-operated group (G-I). G-III rats showed a rapid return to the normal serum creatinine and BUN values on postoperative days 1, 2, 3 and 4. The obtained values in G-III were significantly lower in comparison to the values of G-II and G-IV. The most severe damage (grade 3 to 4) was determined in the kidneys of rats from GII or GIV. The degree of renal tubular damage in GIII was evaluated as grade 1 or 2 tubular damage according to Jablonkski's scale. Our findings suggested that the administration of molsidomine may vanquish the pernicious effects of warm ischemia on kidney structure and function.
Açıklama
Anahtar Kelimeler
Molsidomine, Ng-Monomethyl-L-Arginine, Renal warm ischemia and reperfusion injury
Kaynak
International Urology and Nephrology
WoS Q Değeri
Scopus Q Değeri
Q2
Cilt
32
Sayı
4
Künye
Öztürk, H., Aldemir, M., Büyükbayram, H., Dokucu, A. İ. ve Otçu, S. (2001). The effects of the nitric oxide donor molsidomine prevent in warm ischemia-reperfusion injury of the rat renal - A functional and histopathological study. International Urology and Nephrology, 32(1), 604-607.
