Role of immunohistochemistry for hepatitis D and hepatitis B virus in hepatitis delta

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dc.authoridTR169081en_US
dc.authoridTR172516en_US
dc.authoridTR155837en_US
dc.authoridTR11968en_US
dc.authorid0000-0003-3971-1419en_US
dc.authorid0000-0001-8840-5472en_US
dc.authorid0000-0003-2137-7934en_US
dc.authorid0000-0002-2785-1804en_US
dc.authorid0000-0002-5419-7158en_US
dc.contributor.authorKabaçam, Gökhan
dc.contributor.authorWedemeyer, Heiner
dc.contributor.authorSavaş, Berna
dc.contributor.authorDalekos, George
dc.contributor.authorTabak, Fehmi
dc.contributor.authorİdilman, Ramazan
dc.contributor.authorErhardt, Andreas
dc.contributor.authorYalçın, Kendal
dc.contributor.authorBozdayı, Mithat A.
dc.contributor.authorBozkaya, Hakan
dc.contributor.authorManns, Michael
dc.contributor.authorDienes, Hans
dc.contributor.authorYurdaydın, Cihan
dc.contributor.authorKeskin, Onur
dc.date.accessioned2014-11-10T10:45:04Z
dc.date.available2014-11-10T10:45:04Z
dc.date.issued2014
dc.department0-Belirleneceken_US
dc.description.abstractBackground & Aims: Immunohistochemical assessment of liver tissue in chronic delta hepatitis (CDH) is underinvestigated. Aim of the study was (i) to assess variables associated with hepatitis D antigen (HDAg), hepatitis B surface antigen (HBsAg) and hepatitis B core antigen (HBcAg) staining in the liver. Methods: Demographic, biochemical and virologic data collected from the HIDIT 1 study were used. HBsAg, HBcAg and HDAg immunohistochemical (IHC) staining was semiquantitatively assessed. Results: Hepatitis D antigen immunohistochemical staining displayed positive correlations with age and alanine aminotransferase (ALT) and negative correlations with serum HBsAg (P = 0.01 for all). HBsAg IHC displayed a negative correlation with gamma glutamyl transferase and positive correlations with serum HBV DNA, serum HBsAg levels and HBeAg serology (P < 0.001, P = 0.02 and P = 0.007 respectively). HBcAg staining was mainly nuclear and displayed negative correlations with serum HBsAg and histologic activity (P = 0.002 and P = 0.02 respectively). Pegylated IFN based treatment led to a decline of all IHC markers, however, these markers had no impact on treatment outcome. Conclusions: These data suggest an association of liver injury with HDAg expression in CDH whereas the negative correlation between HBcAg expression and liver injury and the overall nuclear localization of HBcAg suggest that HBcAg does not contribute to liver injury in CDH. HDV cases with high level of HBV replication, high serum HBsAg levels, HBeAg positivity, that are probably in the earlier stages of disease (low gamma-glutamyl transferase), had a more intense HBsAg staining profile. Overall, the data enforce the importance of HDAg and HBsAg in different phases of CDH infection.en_US
dc.identifier.doi10.1111/liv.12376
dc.identifier.pmid24308704
dc.identifier.scopus2-s2.0-84905722781
dc.identifier.scopusqualityN/A
dc.identifier.urihttps://hdl.handle.net/11468/324
dc.identifier.urihttp://onlinelibrary.wiley.com/doi/10.1111/liv.12376/pdf
dc.identifier.wosWOS:000342578100009
dc.identifier.wosqualityQ1
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthor0-Belirlenecek
dc.language.isoenen_US
dc.publisherWILEY-BLACKWELL, 111 RIVER ST, HOBOKEN 07030-5774, NJ USAen_US
dc.relation.publicationcategory0-Belirleneceken_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectChronic Delta Hepatitisen_US
dc.subjectDelta Antigenen_US
dc.subjectHBcAgen_US
dc.subjectHBsAg;en_US
dc.subjectImmunohistochemistryen_US
dc.subjectQuantitative Surface Antigenen_US
dc.titleRole of immunohistochemistry for hepatitis D and hepatitis B virus in hepatitis deltaen_US
dc.titleRole of immunohistochemistry for hepatitis D and hepatitis B virus in hepatitis delta
dc.typeArticleen_US

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