Tarantula cubensis extract alters the degree of apoptosis and mitosis in canine mammary adenocarcinomas

Basit Öğe Kaydı
dc.contributor.authorGultiken, Nilgun
dc.contributor.authorGuvenc, Tolga
dc.contributor.authorKaya, Duygu
dc.contributor.authorAgaoglu, Ali Reha
dc.contributor.authorAy, Serhan Serhat
dc.contributor.authorKucukaslan, Ibrahim
dc.contributor.authorEmre, Birten
dc.date.accessioned2024-04-24T17:24:18Z
dc.date.available2024-04-24T17:24:18Z
dc.date.issued2015
dc.departmentDicle Üniversitesien_US
dc.description.abstractIn the present study, 13 clinical cases of canine mammary adenocarcinoma were evaluated in order to understand the effect of Tarantula cubensis extract (TOE) on tumor tissue. Punch biopsies were taken from the tumors before treatment with TOE. Subcutaneous injections of TOE were administered three times at weekly intervals (3 mL per dog). Between days 7 and 10 after the third injection, the tumor masses were extirpated by complete unilateral mastectomy. Pre- and post-treatment tumor tissues were immunohistochemically assessed. The expression of B-cell lymphoma 2 (Bcl.2) was found to be higher in pre-treatment compared to post-treatment tissues (p <0.01) whereas Ki-67 expression was lower in post-treatment tissues (p < 0.01). No significant differences in fibroblast growth factor or vascular endothelial growth factor expression were observed between pre- and post-treatment tissues (p > 0.05). The apoptotic index was determined to be low before treatment and increased during treatment. These results suggest that TOE may be effective for controlling the local growth of canine mammary adenocarcinoma by regulating apoptosis.en_US
dc.identifier.doi10.4142/jvs.2015.16.2.213
dc.identifier.endpage219en_US
dc.identifier.issn1229-845X
dc.identifier.issn1976-555X
dc.identifier.issue2en_US
dc.identifier.pmid25549212
dc.identifier.scopus2-s2.0-84934274116
dc.identifier.scopusqualityQ1
dc.identifier.startpage213en_US
dc.identifier.urihttps://doi.org/10.4142/jvs.2015.16.2.213
dc.identifier.urihttps://hdl.handle.net/11468/19590
dc.identifier.volume16en_US
dc.identifier.wosWOS:000356905600011
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherKorean Soc Veterinary Scienceen_US
dc.relation.ispartofJournal of Veterinary Science
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectApoptosisen_US
dc.subjectCanineen_US
dc.subjectMammary Tumorsen_US
dc.subjectTarantula Cubensisen_US
dc.titleTarantula cubensis extract alters the degree of apoptosis and mitosis in canine mammary adenocarcinomasen_US
dc.titleTarantula cubensis extract alters the degree of apoptosis and mitosis in canine mammary adenocarcinomas
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu