Screening of C2-symmetric chiral phosphinites as ligands for ruthenium(II)-catalyzed asymmetric transfer hydrogenation of prochiral aromatic ketones
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Tarih
2013
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Elsevier Science Sa
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Metal-catalyzed transfer hydrogenation processes provide a widely-used alternative to direct hydrogenation processes of ketones. As part of an ongoing program, we report enantioselective C-2-symmetric bis(phosphinite)-ruthenium(II) catalytic systems for the transfer hydrogenation of prochiral aromatic ketones. The new catalytic systems can readily be formed under in situ conditions from C-2-symmetric chiral bis(phosphinite) ligands and [Ru(eta(6)-p-cymene)(mu-Cl)Cl](2) in transfer hydrogenation reaction media. These chiral ruthenium catalytic systems serve as catalyst precursors for the asymmetric transfer hydrogenation of acetophenone derivatives in iso-PrOH and giving the corresponding optical active secondary alcohols up to 94% ee. (C) 2013 Elsevier B.V. All rights reserved.
Açıklama
Anahtar Kelimeler
Catalysis, Asymmetric Transfer Hydrogenation, Chiral Phosphinite Ligand, Ruthenium, C-2-Symmetry
Kaynak
Journal of Organometallic Chemistry
WoS Q Değeri
Q2
Scopus Q Değeri
Q2
Cilt
729
