İmipenem ilişkili konvülziyon: Olgu sunumu

Beta-laktam grubu antibiyotiklerinin nadir görülen yan etkilerinden biri de konvülziyondur. Acil servise yüksek atefl, öksürük ve solunum s›k›nt›s›yla gelen dokuz yafl›nda erkek hasta ampiyem tan›s›yla yat›r›lm›fl, ampiyem materyalinden yap›lan kültürde GSBL positif Pseudomonas aeruginosa üremifltir. Tedavide imipenem/silastatin ile birlikte amikasin verilmifltir. Klinik ve laboratuvar olarak düzelen hastada tedavinin 18. gününde tonik-klonik kas›lmalarla seyreden konvülziyon geliflmifl, konvülziyonlar imipenem/silastatin tedavisine ba¤lanm›fl ve antibiyoterapi kesilmifltir. Antiepileptik tedavi bafllanan hastada yap›lan incelemelerde konvülziyonu aç›klayacak baflka bir patoloji bulunamam›flt›r. Hasta yat›fl›n›n 21. gününde flifa ile tabucu edilmifltir.

Convulsion is an infrequent side effect of beta-lactam antibiotics. A nine-years-old boy patient admitted to the emergency room with fever, coughing, and dyspnea. Patient was hospitalized with diagnosis of empyema and ESBL positive Pseudomonas aeruginosa was isolated on blood agar culture of empyema material. The patient was treated with imipenem/cilastatin and amikacin and improved clinically, but developed convulsion with tonic-clonic myospasms at 18th day of therapy. The treatment of imipenem withdrawn because of its close relation with convulsions, and antiepileptic therapy was started. We could not find any other possible etiologic cause of convulsion by physical examination and laboratory evaluation. The patient was discharged with full recovery at 21th day of hospitalization.