Evaluation of clinical and laboratory findings in the differential diagnosis of central precocious puberty and premature thelarche
Yükleniyor...
Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Wolters Kluwer Medknow Publications
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, it was aimed to examine the clinical and laboratory findings that can be used to predict central precocious puberty (CPP) in
cases whose breast development started before the age of 8. Materials and Methods: The chronological age, anthropometric measurements, bone
age (BA), hormone test results and pelvic ultrasonography findings of the cases were recorded. Those with a peak luteinizing hormone (LH) level
of ≥5 IU/L in the gonadotropin‑releasing hormone (GnRH) stimulation test were classified as CPP and those with a peak LH level of <5 IU/L
were classified as prepubertal cases. A receiver operating characteristic (ROC) analysis was performed to determine the diagnostic accuracy
of laboratory variables. Findings: A total of 297 female cases were included in the study. The age at the time of admission, height‑standard
deviation score (SDS), BA, the long axis of the uterus and the volumes of the right and left ovaries of the cases diagnosed with CPP were found
to be significantly higher than those of the prepubertal group. The cut‑off value providing the best sensitivity (99%) and specificity (99%) for the
peak LH was found to be 4.55; the cut‑off value providing the best sensitivity (94%) and specificity (85%) for the peak LH/follicle‑stimulating
hormone (FSH) ratio was found to be 0.32 and the cut‑off value providing the best sensitivity (47%) and specificity (93%) for the basal LH
was found to be 0.13. Conclusion: We believe that in female cases with early breast development, a peak LH level of ≥4.55 may possibly
indicate CPP and a basal LH level of <0.13 can significantly rule out CPP.
Açıklama
Anahtar Kelimeler
Central precocious puberty, GnRH stimulation test, Puberty
Kaynak
Indian Journal of Endocrinology and Metabolism
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
27
Sayı
3
Künye
Beştaş, A., Ünal, E., Karakaya, A. A., Demiral, M. ve Haspolat, Y. K. (2023). Evaluation of clinical and laboratory findings in the differential diagnosis of central precocious puberty and premature thelarche. Indian Journal of Endocrinology and Metabolism, 27(3), 237-241.
