Interaction of nitric oxide and cell adhesion molecules after 24 hours of complete ureteric obstruction in the rats on a solitary kidney

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dc.contributor.authorÖztürk, Hayrettin
dc.contributor.authorDokucu, Ali İhsan
dc.contributor.authorBüyükbayram, Hüseyin
dc.date.accessioned2024-04-24T17:56:13Z
dc.date.available2024-04-24T17:56:13Z
dc.date.issued2001
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Cerrahi Tıp Bilimleri Bölümü, Çocuk Cerrahisi Ana Bilim Dalıen_US
dc.description.abstractWe aimed to show whether the administration of exogenous L-Arg would alter the morphological, functional changes and interaction of nitric oxide and cell adhesion molecules such as tenascin and lectin after release of twenty-four hours complete ureteric obstruction in the solitary rat kidney tissue. Forty prepubertal Wistar-Albino rats were separated into 4 groups, each containing 10 rats. In the group 1 (Sham-control, n = 10), right nefrectomy was performed; the left ureter was visualized but not ligated. In the remaining 30 rats, the abdomen was opened and undergone right nephrectomy and the left ureter was completely obstructed. After 24 hours, thirty rats were divided as group 2, 3, and 4, each containing 10 rats. In-group 2, no drug treatments were given. In-group 3 L-Arg (L-arginine methyl ester) was infused immediately after abolishing ureteric obstruction. In-group 4 L-NAME was given separately during L-Arg administration during 30 minutes immediately after abolishing ureteric obstruction. Than, the animals were prepared for functional and histopathological studies. BUN value was decreased significantly in L-Arg group when compared with untreatment and L-NAME groups (p < 0.05, p < 0.001 respectively). Creatinine values were decreased in L-Arg group when compared with untreatment group (p < 0.002). Urine flow and urinary Na value was increased significantly in L-Arg group when compared to other obstruction groups (p < 0.001, p < 0.001). The increase in the number of macrophages in Untreated and L-NAME group were significant (p < 0.001, p < 0.001) when compared to L-Arg group. Immunohistochemical study showed that tenascin and lectin expression was severe in tubulus basal membrane of untreated and L-NAME treated rats. In L-Arg group, tenascin and lectin expression was moderate in tubulus membrane. Our results suggest that the administration of exogenous L-Arg protect the functional and degenerative effects of acute complete obstruction in the solitary kidney tissue of the rats. Nitric oxide cause these positive effects by decreasing preglomerular vascular resistance, regulation of neutrophil function and preventing the expression of cell adhesion molecules such as tenascin and lectin.en_US
dc.identifier.citationÖztürk, H., Dokucu, A. İ. ve Büyükbayram, H. (2001). Interaction of nitric oxide and cell adhesion molecules after 24 hours of complete ureteric obstruction in the rats on a solitary kidney. International Urology and Nephrology, 33(3), 435-443.
dc.identifier.doi10.1023/A:1019515323397
dc.identifier.endpage443en_US
dc.identifier.issn0301-1623
dc.identifier.issue3en_US
dc.identifier.pmid12230267
dc.identifier.scopus2-s2.0-0035545313
dc.identifier.scopusqualityQ2
dc.identifier.startpage435en_US
dc.identifier.urihttps://doi.org/10.1023/A:1019515323397
dc.identifier.urihttps://hdl.handle.net/11468/23374
dc.identifier.urihttps://link.springer.com/article/10.1023/A:1019515323397
dc.identifier.volume33en_US
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.relation.ispartofInternational Urology and Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCell Adhesion Moleculesen_US
dc.subjectL-Arginine Methyl Esteren_US
dc.subjectLectinen_US
dc.subjectN-Nitro-L-Arginine Methyl Esteren_US
dc.subjectNitric oxideen_US
dc.subjectRaten_US
dc.subjectTenascinen_US
dc.subjectUreteric obstructionen_US
dc.titleInteraction of nitric oxide and cell adhesion molecules after 24 hours of complete ureteric obstruction in the rats on a solitary kidneyen_US
dc.titleInteraction of nitric oxide and cell adhesion molecules after 24 hours of complete ureteric obstruction in the rats on a solitary kidney
dc.typeArticleen_US

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