The effects of mucosal media on some pathogenic traits of Crohn's disease-associated Escherichia coli LF82
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Tarih
2018
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Future Medicine Ltd
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Aim: Adherent-invasive Escherichia coli (AIEC) pathovar has been identified in intestinal mucosa of patients with Crohn's disease. Our aim was to compare the impact of sterile mucosal media (Muc-M) originated from different parts of the intestine on some pathogenic traits of AIEC LF82 strain. Materials & methods: Muc-M composed of certain rates of cell culture medium or M63 minimal medium and mucosal contents obtained from different part of intestine were designed for cell-infection experiments and biofilm-formation assays. Results: The results showed that Muc-M reduced usually pathogenic properties of AIEC LF82. However, LF82 adhesion, invasion and specific biofilm formations were markedly higher in Muc-MCR than those in Muc-MIR. Conclusion: In this context, the findings of present study could help the endeavors related to determining molecular targets for AIEC bacteria.
Açıklama
Anahtar Kelimeler
Adhesion, Biofilm, Crohn's Disease, Escherichia Coli Lf82, Invasion, Pathobiont
Kaynak
Future Microbiology
WoS Q Değeri
Q3
Scopus Q Değeri
Q2
Cilt
13
Sayı
2
