The effects of glucose-insulin-potassium solution and BN 52021 in intestinal ischemia-reperfusion injury
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Tarih
2003
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
The objective of this study was to investigate effects of glucose-insulin-potassium (GIK) solution and BN 52021, a platelet-activating factor antagonist, on intestinal ischemia-reperfusion injury. Fifty male Sprague-Dawley rats (200-225 g) were divided into 5 groups each containing 10 rats; group SO, sham operation group; group I, mesenteric ischemia group (for 30 minutes); group R, ischemia plus reperfusion (for 60 minutes); group BR, ischemia-reperfusion plus BN 52021; group GR, ischemia-reperfusion plus GIK solution. Samples for malondialdehyde (MDA) and ileum (for mucosal injury score) were obtained. The mucosal injury scores of group R were significantly higher than those of group I (4 ±0.20 and 3 ±0.16, respectively, p < 0.0001). The scores of groups BR and GR were significantly lower than those of group R (p < 0.0001 and p < 0.0001, respectively). When it was compared with the injuries in BR and GR groups, similar results were obtained in both groups (p = 0.190). Mean MDA levels of group R were significantly higher than those of group I, BR and GR (131.33 ±3.99 nmol/g, 93.74 ±3.22 nmol/g, 104.81 ±2.56 and 100.34 ±5.30, respectively, p < 0.0001). MDA levels of group BR and GR were significantly lower than those of group I (p < 0.0001 and p = 0.003, respectively). These observations suggest that treatment with GIK solution and BN 52021 before reperfusion and during reperfusion period may be useful in decreasing intestinal reperfusion injury.
Açıklama
Anahtar Kelimeler
Kaynak
Vascular and Endovascular Surgery
WoS Q Değeri
Scopus Q Değeri
Q3
Cilt
37
Sayı
5
Künye
Aldemir, M., Gürel, A., Büyükbayram, H. ve Taçyıldız, İ. (2003). The effects of glucose-insulin-potassium solution and BN 52021 in intestinal ischemia-reperfusion injury. Vascular and Endovascular Surgery, 37(5), 345-351.
