The insertion/deletion polymorphism in the ACE gene and chronic obstructive pulmonary disease

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dc.contributor.authorSimsek, S.
dc.contributor.authorTekes, S.
dc.contributor.authorOral, D.
dc.contributor.authorTurkyilmaz, A.
dc.contributor.authorIsik, B.
dc.contributor.authorIsik, M. R.
dc.contributor.authorAkkoc, H.
dc.date.accessioned2024-04-24T17:24:22Z
dc.date.available2024-04-24T17:24:22Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractAn insertion/deletion (I/D) polymorphism was identified in intron 16 of the gene encoding the human angiotensin I-converting enzyme (ACE), a candidate gene for chronic obstructive pulmonary disease (COPD). We investigated the relationship between this polymorphism in the ACE gene and the risk of developing COPD. Sixty-six COPD in-patients and 40 non-smoking control individuals were recruited for this study. The distribution of ACE genotypes in these individuals was studied. The frequencies of ACE genotypes were found to be 47.0% for DD, 30.3% for ID, and 22.7% for II in the COPD group and 32.5% for DD, 47.5% for ID, and 20.0% for II in the control group. The allele frequencies were found to be 0.62% for the D allele and 0.38% for the I allele in the COPD group and 0.56% for the D allele and 0.44% for the I allele in the control group. A significant difference was found between I and D allele frequencies (P < 0.05) of the study and control groups. Our results suggest that this ACE polymorphism may be associated with the development of COPD.en_US
dc.identifier.doi10.4238/2013.April.25.10
dc.identifier.endpage1398en_US
dc.identifier.issn1676-5680
dc.identifier.issue2en_US
dc.identifier.pmid23661462
dc.identifier.scopus2-s2.0-84876874933
dc.identifier.scopusqualityQ4
dc.identifier.startpage1392en_US
dc.identifier.urihttps://doi.org/10.4238/2013.April.25.10
dc.identifier.urihttps://hdl.handle.net/11468/19632
dc.identifier.volume12en_US
dc.identifier.wosWOS:000320030100053
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherFunpec-Editoraen_US
dc.relation.ispartofGenetics and Molecular Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAce Geneen_US
dc.subjectChronic Obstructive Pulmonary Diseaseen_US
dc.subjectPolymorphismen_US
dc.titleThe insertion/deletion polymorphism in the ACE gene and chronic obstructive pulmonary diseaseen_US
dc.titleThe insertion/deletion polymorphism in the ACE gene and chronic obstructive pulmonary disease
dc.typeArticleen_US

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