Effects of nimodipine and ofloxacin on staphylococcal brain abscesses in rats

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dc.contributor.authorCeviz, A
dc.contributor.authorInalöz, SS
dc.contributor.authorÇiçek, R
dc.contributor.authorSari, I
dc.contributor.authorGül, K
dc.contributor.authorSanli, A
dc.date.accessioned2024-04-24T17:33:43Z
dc.date.available2024-04-24T17:33:43Z
dc.date.issued1997
dc.departmentDicle Üniversitesien_US
dc.description.abstractThe therapeutic effects of nimodipine (GAS 66085-59-4) and ofloxacin (GAS 82419-36-1) were investigated against experimental brain abscess formation in rats. Nimodipine, a 1,4-dihydropyridine derivative, is chemically related to nifedipine but the smooth muscle relaxant effect preferentially acts on cerebral arteries. Ofloxacin is a member of 4-Quinolone broad spectrum antibiotics. Ninety-six male Sprague-Dawley rats were inoculated intracortically with Staphylococcus aureus and then different groups were treated with either saline. ofloxacin or the combination of ofloxacin and nimodipine. The rate of brain abscess formation and mortality were considerably decreased by nimodipine and ofloxacin therapy. Combination therapy was found histologically to be considerably more effective than ofloxacin alone against brain abscess formation in rats.en_US
dc.identifier.endpage1405en_US
dc.identifier.issn0004-4172
dc.identifier.issue12en_US
dc.identifier.pmid9450172
dc.identifier.scopus2-s2.0-0031441545
dc.identifier.scopusqualityN/A
dc.identifier.startpage1402en_US
dc.identifier.urihttps://hdl.handle.net/11468/20813
dc.identifier.volume47en_US
dc.identifier.wosWOS:000071834400012
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherEcv-Editio Cantor Verlag Medizin Naturwissenschaftenen_US
dc.relation.ispartofArzneimittel-Forschung-Drug Research
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBrain Abscessen_US
dc.subjectCas 66085-59-4en_US
dc.subjectCas 82419-36-1en_US
dc.subjectNimodipineen_US
dc.subjectOfloxacinen_US
dc.subjectStaphylococcus Aureusen_US
dc.titleEffects of nimodipine and ofloxacin on staphylococcal brain abscesses in ratsen_US
dc.titleEffects of nimodipine and ofloxacin on staphylococcal brain abscesses in rats
dc.typeArticleen_US

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