Çocukluk çağı akut immün trombositopenik purpura da tedavi protokollerinin irdelenmesi
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Tarih
1999
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Galenos Yayıncılık
Erişim Hakkı
info:eu-repo/semantics/closedAccess
Özet
Dicle Üniversitesi Tıp Fakültesi Çocuk Sağlığı ve Hastalıkları Anabilim Dalı Hematoloji -Onkoloji bölümünde 1991-1998 yılları arasında izlenen 104 Akut immün trombositopenik purpuralı (48'i kız, 56'sı erkek) olgumuzun tedavi sonuçları retrospektif olarak değerlendirildi. Olguların yaşları 2 ay-14 yaş (ort 4.8±0.5 yıl) idi. Bir olgu hastanemize başvurduğu gün intrakranial kanama nedeni ile eks oldu. 41 hastada (%39) spontan remisyon görüldü. Olgularımızın 29'una (%28) 0.5-1 gr/kg/gün dozda intravenöz immünglobulin, 21'ine (%20) standart doz oral prednizolon, 12(%11) olgumuza ise yüksek doz metil prednizolon tedavisi uygulandı. İntravenöz immünglobulin alan 29 hastanın 25'inde (%86) ilk yanıt elde edilirken , 6. aydaki remisyon oranı 24 hasta (%83) olarak saptandı. Standart doz oral steroid ile tedavi edilen hastalarda ilk yanıt 16 hastada sağlanırken (%76), 6. aydaki remisyon oranı 14 (%66) hasta olarak bulundu, intravenöz yüksek doz metil prednizolon alan olgularımızda ilk yanıt 11 hastada sağlanırken (%91) 6.aydaki remisyon oranı 11 hastada, (%91) olarak saptandı. 13 olgu kronikleşti.
One hundred and four children (48 female£6 male) followed-up with acute Immun thrombocytopenic purpura in hematology-oncology ward of departmanı of pediatric in Dicle University medical school during 1991-1998 were evaluated retrospectively . Age of the cases ranged between 2 months and 14 years (mean:4.8±0.5 years). One of the cases was exitusfrom intracranial bleeding at time of hospitalization. Forty-one (39%) of the patients had spontaneous remission. Intravenous immunoglobulin at 0.5-lgr/kg/day doses was administrated in 29 (28%) cases oral prednisolon at standard doses in 21 (20%) and high dose methyl prednisolon in 12(11%) cases. Twenty-five (86%) of the 29 patients who had intravenous immunoglobulin therapy responded well and 24 the patients (83%) were at remission during 6 months after therapy. In the standard dose oral steroid given group 16 (76%) of the patients responded well first and 14 (66%) patients were at remission at the sixth months. Eleven (91 %) of the patients who had intravenous high dose methyl prednisolon gave a good first response, and all of these cases were at remission in 6 months of follow-up. A total of 13 cases were accepted as having chronic immun trombocytopenic purpura.
One hundred and four children (48 female£6 male) followed-up with acute Immun thrombocytopenic purpura in hematology-oncology ward of departmanı of pediatric in Dicle University medical school during 1991-1998 were evaluated retrospectively . Age of the cases ranged between 2 months and 14 years (mean:4.8±0.5 years). One of the cases was exitusfrom intracranial bleeding at time of hospitalization. Forty-one (39%) of the patients had spontaneous remission. Intravenous immunoglobulin at 0.5-lgr/kg/day doses was administrated in 29 (28%) cases oral prednisolon at standard doses in 21 (20%) and high dose methyl prednisolon in 12(11%) cases. Twenty-five (86%) of the 29 patients who had intravenous immunoglobulin therapy responded well and 24 the patients (83%) were at remission during 6 months after therapy. In the standard dose oral steroid given group 16 (76%) of the patients responded well first and 14 (66%) patients were at remission at the sixth months. Eleven (91 %) of the patients who had intravenous high dose methyl prednisolon gave a good first response, and all of these cases were at remission in 6 months of follow-up. A total of 13 cases were accepted as having chronic immun trombocytopenic purpura.
Açıklama
Anahtar Kelimeler
Akut immun trombositopenik purpura, Tedavi, Acute immun thorombocytopenic purpura, Treatment
Kaynak
Haseki Tıp Bülteni
WoS Q Değeri
Scopus Q Değeri
Cilt
37
Sayı
1
Künye
Söker, M., Devecioğlu, C., Haspolat, Y. K., Yaramış, A. ve Taş, M. A. (1999). Çocukluk çağı akut immün trombositopenik purpura da tedavi protokollerinin irdelenmesi. Haseki Tıp Bülteni, 37(1), 27-31.
