The histological structure of circumvallate papillae of the puppy rats which were born from the rats given egf after sialoadenectomy

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dc.contributor.authorAktaş, Ayfer
dc.contributor.authorNegriz, Y.
dc.contributor.orcid0000-0002-3280-1430
dc.date.accessioned2024-04-24T17:56:21Z
dc.date.available2024-04-24T17:56:21Z
dc.date.issued2006
dc.departmentDicle Üniversitesi, Tıp Fakültesi, Temel Tıp Bilimleri Bölümü, Histoloji ve Embriyoloji Ana Bilim Dalıen_US
dc.description.abstractThe papillaries on the dorsal surface of tongue are constantly washed by saliva rich in Epidermal Growth Factor (EGF). After the complete removal of submandibular gland surgically (Sialoadenectomy), morphological alterations, and the effects of EGF given orally on these alterations were investigated. In the study, 30 adult female Spraque-Dawley rats were used, which were divided into three groups: Control group (n=10); sialoadenectomy group (SX, n= 10); sialoadenectomy + epidermal growth factor group (SX+EGF, n=10). Following a three week period of recovery, the rats were mated. On days 16–19th of pregnancy, a total of 5 microgram (?g) EGF was given to the animals in SX + EGF group with orogastric tub as 1.25?g daily to each animal. The fetuses born following pregnancy were kept to grow up until the 28th day. The pupy rat of 28 days in all groups were sacrificed. Tongues of all tree group were dissected and specimes separetly put into %10 neutral bufferd formalin solution. The paraffin section obtained through routine histological methods were stained with Hematoxylen—Eosine (H.E), Methylen blue- Basic Fuchsin, and were examined under light microscope. No pathology could be observed on the circumvallate papillae of control group. The observation revealed that the circumvallate papillae of SX group usually displayed an atrophic situation, and there was perforation, particularly in the apical epithelial. The degeneretion in the epithelial made itself felt on the opposite wall of the trench. The trench surrounding the papilla was noticeably blocked in patches, and its depth and the surface area was diminished considerably when compared to the control group. A significant increase in the keratinization was detected on the surface epithelial of the circumvallate papilla. On the microscopic examination of the circumvallate papillae of the SX+EGF group rats, it was observed that these papillae had acquired to be similar that of the control group.en_US
dc.identifier.citationAktaş, A. ve Negriz, Y. (2006). The histological structure of circumvallate papillae of the puppy rats which were born from the rats given egf after sialoadenectomy. Biotechnology and Biotechnological Equipment, 20(3), 137-141.
dc.identifier.doi10.1080/13102818.2006.10817391
dc.identifier.endpage141en_US
dc.identifier.issn1310-2818
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-33846331613
dc.identifier.scopusqualityQ3
dc.identifier.startpage137en_US
dc.identifier.urihttps://doi.org/10.1080/13102818.2006.10817391
dc.identifier.urihttps://hdl.handle.net/11468/23464
dc.identifier.urihttps://www.tandfonline.com/doi/abs/10.1080/13102818.2006.10817391
dc.identifier.volume20en_US
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.relation.ispartofBiotechnology and Biotechnological Equipment
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.titleThe histological structure of circumvallate papillae of the puppy rats which were born from the rats given egf after sialoadenectomyen_US
dc.titleThe histological structure of circumvallate papillae of the puppy rats which were born from the rats given egf after sialoadenectomy
dc.typeArticleen_US

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