The role of cell adhesion molecules in ischemic epididymal injury

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dc.contributor.authorOzturk, Hayrettin
dc.contributor.authorOzturk, Hulya
dc.contributor.authorDokucu, Ali Ihsan
dc.date.accessioned2024-04-24T16:02:24Z
dc.date.available2024-04-24T16:02:24Z
dc.date.issued2007
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective The aim of this study was to investigate the role of adhesion molecules in epididymal injury induced by I-R in the rats. Study design A total of 20 male Sprague-Dawley rats were separated into two groups. A sham operation was performed in group 1 (control). In group 2 (I-R), following 6 h of unilateral spermatic cord torsion, 1-h detorsion of the testis was performed. Then, epididymides were removed to measure the tissue levels of malondialdehyde (MDA) and to make histological examination. Results MDA values increased in the group 2. In the group 2 rats demonstrated significant disorganization of the epithelium and loss of microvilli in the epididymal tissue. No abnormal microscopic findings of the epididymis of the rats in the control group. The tenascin expression in the interstitial area of the epididymis was intense in the group 2. ICAM-1 expression by intense brown staining was seen along the basement membrane in epididymal tissue from I to R group rats. The microvillus sites of the epithelia in I-R group were stained mildly by lectin. Conclusion The increased expression of adhesion molecules found in epididymal injury induced during postischemic reperfusion might implicate importance of inflammatory infiltration.en_US
dc.identifier.doi10.1007/s11255-006-9024-6
dc.identifier.endpage570en_US
dc.identifier.issn0301-1623
dc.identifier.issue2en_US
dc.identifier.pmid17043920
dc.identifier.scopus2-s2.0-34447309705
dc.identifier.scopusqualityQ2
dc.identifier.startpage565en_US
dc.identifier.urihttps://doi.org/10.1007/s11255-006-9024-6
dc.identifier.urihttps://hdl.handle.net/11468/14777
dc.identifier.volume39en_US
dc.identifier.wosWOS:000247976000046
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Urology and Nephrology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectTesticular And Spermatic Cord Torsionen_US
dc.subjectAdhesion Moleculesen_US
dc.subjectRaten_US
dc.titleThe role of cell adhesion molecules in ischemic epididymal injuryen_US
dc.titleThe role of cell adhesion molecules in ischemic epididymal injury
dc.typeArticleen_US

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