Separation of Line Widths of HOD Peaks of Healthy and Diseased Blood and Urine Groups Using 400 MHz NMR

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dc.contributor.authorSakar, Mehmet Nafi
dc.contributor.authorYilmaz, Utku Nezih
dc.contributor.authorKoylu, Mehmet Zafer
dc.date.accessioned2025-02-22T14:09:06Z
dc.date.available2025-02-22T14:09:06Z
dc.date.issued2025
dc.departmentDicle Üniversitesien_US
dc.description.abstractLine width studies of high field nuclear magnetic resonance (NMR) peaks have been seen more frequently in the recent literature. This study aims to compare the NMR line widths of HOD peaks of healthy and diseased blood, and densely bloody cysts taken from the jaw. Comparisons of HOD peak line widths in healthy and diseased urine were also made. For this purpose, the blood, serum, and urine of 29 cancer patients, 17 diabetic patients, 28 healthy volunteers, and 20 intensely bloody samples from jaw cysts were collected. Mixtures were prepared by adding the 0.02-mL sample to 0.98 mL D2O. Single-pulse proton NMR measurements were performed at 400 MHz, and line widths were obtained from the half-height of the blood HOD peak. Statistical evaluations show that the line width of cancerous blood is different from normal blood (P = 0.032), while the line width of diabetic blood is not different (p = 0.072), whereas other groups and bloody jaw cysts are completely different (p < 0.05). Similar results were found for urine groups. Line widths show a moderate correlation with each of the albumin and total protein groups (R around 0,56). Present data suggest that a comparison of healthy and diseased body fluids can be made by line width measurements of the HOD peak in the high NMR field. Data also suggest that the relaxivities of albumin (Ser-Alb), total protein (Ser-TP) are potential diagnostic indicators for cancerous blood.en_US
dc.identifier.doi10.1007/s10812-025-01861-w
dc.identifier.endpage1368en_US
dc.identifier.issn0021-9037
dc.identifier.issn1573-8647
dc.identifier.issue6en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage1362en_US
dc.identifier.urihttps://doi.org/10.1007/s10812-025-01861-w
dc.identifier.urihttps://hdl.handle.net/11468/29794
dc.identifier.volume91en_US
dc.identifier.wosWOS:001397328200001
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofJournal of Applied Spectroscopyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.snmzKA_WOS_20250222
dc.subject400 MHz NMRen_US
dc.subjectmixtures with excessive D2Oen_US
dc.subjectline widthsen_US
dc.subjectblooden_US
dc.subjecturineen_US
dc.subjectbloody cystsen_US
dc.titleSeparation of Line Widths of HOD Peaks of Healthy and Diseased Blood and Urine Groups Using 400 MHz NMRen_US
dc.typeArticleen_US

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