Altered Expression of ADAMTSs and HAPLNs in Preeclamptic Placenta

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dc.contributor.authorKandemir, Sevgi Irtegun
dc.contributor.authorTaskin, Irmak Icen
dc.contributor.authorPektanc, Gulsum
dc.contributor.authorTekin, Mehmet Ali
dc.contributor.authorDemircan, Kadir
dc.date.accessioned2024-04-24T17:27:27Z
dc.date.available2024-04-24T17:27:27Z
dc.date.issued2018
dc.departmentDicle Üniversitesien_US
dc.description.abstractObjective: Preeclampsia (PE) is a pregnancy-specific complication defined by the new onset of hypertension and proteinuria during the second trimester of pregnancy. The pathogenesis of PE remains poorly understood. Revealing the key factors involved in placental dysfunction is critical for the understanding the pathogenesis of PE. The aim of this study was to determine the expression levels of ADAMTSs and their molecular partners, TIMP-3 and HAPLNs in the placental tissues of women with PE. Materials and Methods: Experimental research was conducted on control and preeclamptic placentas. A total of 10 control and 10 preeclamptic placentas were included in the present study. The expression levels of ADAMTSs, HAPLNs, and TIMP-3 were analyzed in two groups by Western blot. Results: The expression levels of ADAMTS-4, -8, -10, -12, -13, -14, -16, and -19 were considerably lower, whereas the expression levels of HAPLN-1, -2, and -4; ADAMTS-18; and TIMP-3 were significantly higher in preeclamptic placentas than in controls. Conclusion: Altered expression levels of ADAMTSs and their molecular partners, TIMP-3 and HAPLNs, may contribute to the pathogenesis of PE.en_US
dc.identifier.doi10.5152/etd.2018.0126
dc.identifier.endpage92en_US
dc.identifier.issn2149-2247
dc.identifier.issn2149-2549
dc.identifier.issue2en_US
dc.identifier.startpage87en_US
dc.identifier.trdizinid305139
dc.identifier.urihttps://doi.org/10.5152/etd.2018.0126
dc.identifier.urihttps://search.trdizin.gov.tr/yayin/detay/305139
dc.identifier.urihttps://hdl.handle.net/11468/19944
dc.identifier.volume40en_US
dc.identifier.wosWOS:000440341300007
dc.identifier.wosqualityN/A
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakTR-Dizin
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofErciyes Medical Journal
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdamtssen_US
dc.subjectTimp-3en_US
dc.subjectHaplnsen_US
dc.subjectPreeclampsiaen_US
dc.subjectPlacentaen_US
dc.titleAltered Expression of ADAMTSs and HAPLNs in Preeclamptic Placentaen_US
dc.titleAltered Expression of ADAMTSs and HAPLNs in Preeclamptic Placenta
dc.typeArticleen_US

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