Cyclosporin A therapy on idiopathic thrombotic thrombocytopenic purpura in the relapse setting: two case reports and a review of the literature

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dc.contributor.authorYilmaz, Murvet
dc.contributor.authorEskazan, Ahmet Emre
dc.contributor.authorUnsal, Abdulkadir
dc.contributor.authorTaninmis, Hakan
dc.contributor.authorKara, Ekrem
dc.contributor.authorCetiner, Mustafa
dc.contributor.authorFerhanoglu, Burhan
dc.date.accessioned2024-04-24T17:11:36Z
dc.date.available2024-04-24T17:11:36Z
dc.date.issued2013
dc.departmentDicle Üniversitesien_US
dc.description.abstractBackgroundThrombotic thrombocytopenic purpura (TTP) is a life-threatening disease, characterized by microangiopathic hemolytic anemia, thrombocytopenia, fever, neurologic disturbances, and renal failure. Plasma therapy has dramatically improved prognosis of TTP, whereas recurrent acute episodes still occur in approximately 40% of patients. Moreover, patients with acquired ADAMTS13 deficiency, which is a significant factor for relapse, may require additional immunosuppressive treatment to get a durable remission. Study Design and MethodsWe hereby report two patients with a history of relapsed idiopathic TTP, who both received cyclosporin A (CSA) as a prophylactic manner after the remission was achieved. We also discuss the efficacy of CSA in patients with relapsed idiopathic TTP with a review of the published literature. ResultsUnder CSA therapy, both patients maintained their clinical remission state, and the ADAMTS13 levels were normalized. ConclusionTo conclude, CSA therapy may be useful for the prevention of relapsed idiopathic TTP in patients with a history of frequent relapses.en_US
dc.identifier.doi10.1111/j.1537-2995.2012.03944.x
dc.identifier.endpage1593en_US
dc.identifier.issn0041-1132
dc.identifier.issue7en_US
dc.identifier.pmid23121663
dc.identifier.startpage1586en_US
dc.identifier.urihttps://doi.org/10.1111/j.1537-2995.2012.03944.x
dc.identifier.urihttps://hdl.handle.net/11468/17629
dc.identifier.volume53en_US
dc.identifier.wosWOS:000321612400028
dc.identifier.wosqualityQ2
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakPubMed
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofTransfusion
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[No Keyword]en_US
dc.titleCyclosporin A therapy on idiopathic thrombotic thrombocytopenic purpura in the relapse setting: two case reports and a review of the literatureen_US
dc.titleCyclosporin A therapy on idiopathic thrombotic thrombocytopenic purpura in the relapse setting: two case reports and a review of the literature
dc.typeArticleen_US

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