Biosynthesis, characterization, and biomedical applications of gold nanoparticles with cucurbita moschata duchesne ex poiret peel aqueous extracts

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Tarih

2024

Dergi Başlığı

Dergi ISSN

Cilt Başlığı

Yayıncı

Mdpi

Erişim Hakkı

info:eu-repo/semantics/openAccess

Özet

In this study, AuNPs were biosynthesized from Cucurbita moschata fruit peel extracts. Biosynthesized AuNPs exhibited maximum absorbance at a 555 nm wavelength, and XRD analysis indicated that the CM-AuNPs had a particle size of less than 100 nm and a cubic crystal structure. TEM scans revealed that the gold particles exhibited a spherical morphology, with an average size of 18.10 nm. FTIR analysis revealed strong peaks indicating the presence of functional groups involved in the reduction reactions. The surface charge of the biosynthesized AuNPs was determined to be -19.7 mV. The antibacterial and antifungal activities of AuNPs against pathogen strains were assessed by the minimum inhibitory concentration (MIC) method. The cytotoxic effects of CM-AuNPs on cancer cell lines (Sk-Ov-3, CaCo2, and A549) and healthy cell lines (HUVEC) were investigated using the MTT method. The findings indicated that AuNPs biosynthesized by the green synthesis method using C. moschata peel aqueous extract had high inhibition on the growth of pathogenic microorganisms and effective cytotoxic activity against cancerous cell lines at low doses. As a result, it can be concluded that CM-AuNPs will be eminently effective in the production of antibacterial and/or anticancer drugs in the pharmaceutical, food, and cosmetic industries.

Açıklama

Anahtar Kelimeler

Green synthesis, Gold nanoparticles, Cucurbita moschata, Antimicrobial, Cytotoxic activity

Kaynak

Molecules

WoS Q Değeri

N/A

Scopus Q Değeri

Q1

Cilt

29

Sayı

5

Künye

Kaval, U. ve Hoşgören, H. (2024). Biosynthesis, characterization, and biomedical applications of gold nanoparticles with cucurbita moschata duchesne ex poiret peel aqueous extracts. Molecules, 29(5), 1-18.