Biosynthesis, characterization, and biomedical applications of gold nanoparticles with cucurbita moschata duchesne ex poiret peel aqueous extracts
Yükleniyor...
Tarih
2024
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Mdpi
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
In this study, AuNPs were biosynthesized from Cucurbita moschata fruit peel extracts. Biosynthesized AuNPs exhibited maximum absorbance at a 555 nm wavelength, and XRD analysis indicated that the CM-AuNPs had a particle size of less than 100 nm and a cubic crystal structure. TEM scans revealed that the gold particles exhibited a spherical morphology, with an average size of 18.10 nm. FTIR analysis revealed strong peaks indicating the presence of functional groups involved in the reduction reactions. The surface charge of the biosynthesized AuNPs was determined to be -19.7 mV. The antibacterial and antifungal activities of AuNPs against pathogen strains were assessed by the minimum inhibitory concentration (MIC) method. The cytotoxic effects of CM-AuNPs on cancer cell lines (Sk-Ov-3, CaCo2, and A549) and healthy cell lines (HUVEC) were investigated using the MTT method. The findings indicated that AuNPs biosynthesized by the green synthesis method using C. moschata peel aqueous extract had high inhibition on the growth of pathogenic microorganisms and effective cytotoxic activity against cancerous cell lines at low doses. As a result, it can be concluded that CM-AuNPs will be eminently effective in the production of antibacterial and/or anticancer drugs in the pharmaceutical, food, and cosmetic industries.
Açıklama
Anahtar Kelimeler
Green synthesis, Gold nanoparticles, Cucurbita moschata, Antimicrobial, Cytotoxic activity
Kaynak
Molecules
WoS Q Değeri
N/A
Scopus Q Değeri
Q1
Cilt
29
Sayı
5
Künye
Kaval, U. ve Hoşgören, H. (2024). Biosynthesis, characterization, and biomedical applications of gold nanoparticles with cucurbita moschata duchesne ex poiret peel aqueous extracts. Molecules, 29(5), 1-18.
