Comparison of C-peptide levels in monogenic forms of diabetes with other types of diabetes: A single-center study
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Tarih
2023
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Acta Endocrinologica Foundation
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Objective. This study aimed to evaluate the utility of C-peptide levels in the differentiation of monogenic forms of diabetes from type 1 diabetes mellitus (T1DM) and type 2 diabetes mellitus (T2DM) in clinical practice. Subjects and Methods. A total of 104 patients aged >16 who visited the Dicle University’s Faculty of Medicine between April 2011 and December 2020 and were diagnosed with monogenic diabetes by genetic analysis or with T1DM and T2DM were randomly selected for retrospective evaluation. The C-peptide levels of these patients at the time of diagnosis of diabetes were compared. Results. Of the 104 patients, 24 (23%) were diagnosed with maturity-onset diabetes of the young (MODY), 40 (38.5%) with T1DM, and 40 (38.5%) with T2DM. Median C-peptide levels (ng/mL) (interquartile range) were 1.78 (1.24-2.88) in MODY group, 0.86 (0.34- 1.22) in T1DM group, and 2.38 (1.58-4.27) in T2DM group. Conclusions. There was a difference in C-peptide levels between MODY and T1DM groups but not between MODY and T2DM groups. As per clinical evaluations, although C-peptide levels of patients with MODY are similar to those of patients with T2DM patients, the possibility of C-peptide levels being similar to those required for T1DM diagnosis should also be considered.
Açıklama
Anahtar Kelimeler
C-Peptide, Mody, Monogenic diabetes, Type 1 diabetes, Type 2 diabetes
Kaynak
Acta Endocrinologica
WoS Q Değeri
Scopus Q Değeri
Q4
Cilt
19
Sayı
3
Künye
Geneş, D., Pekkolay, Z., Şimşek, M., Saraçoğlu, H., Turgut, M., Tekeş, S. ve diğerleri. (2023). Comparison of C-peptide levels in monogenic forms of diabetes with other types of diabetes: A single-center study. Acta Endocrinologica, 19(3), 281-285.
