Major depresif bozuklukta prolidaz aktivitesi
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Tarih
2015
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Modestum Publishing Ltd.
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Amaç: Prolidaz enzimi dipeptitlerin karboksil terminal pozisyondaki prolin veya hidroksiprolini ayıran plazma, beyin ve çeşitli organlarda bulunan bir egzopeptidazdır. Biz
bu çalışmada major depresif bozukluk (MDB)’da prolidaz
aktivitesini araştırmayı amaçladık.
Yöntemler: Çalışmamızda hasta grubu major depresif
bozukluk 22 kişiden oluşurken kontrol grubu ise herhangi bir psikiyatrik rahatsızlığı olmayan sağlıklı 26 kişiden
oluşmaktaydı. Her hasta deneyimli psikiyatristler tarafından ayrıntılı tanısal değerlendirmeye alındı. Hasta ve
kontrol grubuna sosyodemografik bilgi formu verilirken,
hasta grubuna Hamilton Depresyon Derecelendirme Ölçeği (HDDÖ), Hamilton Anksiyete Derecelendirme Ölçeği
(HADÖ), Klinik Global İzlem Ölçeği (KGİ) uygulandı. Biyokimyasal analizler için kan alındı.
Bulgular: Hasta grubunun yaş ortalaması 31,3±10,1
yıl, kontrol grubunun yaş ortalaması ise 32,3±8,8 yıl idi.
Eğitim süresi hasta grubunun 8,1±6,2 yıl, kontrol grubunda 10,2±3,8 yıl idi. Gruplar arasında yaş ve eğitim
süresi açısından istatistiksel olarak anlamlı farklılık belirlenmedi (p>0,05). Prolidaz aktivitesinin hasta grubunda 510.3±480.8 U/L iken kontrol grubunda 457,8±386,0
U/L olduğu görüldü. Prolidaz aktivitesi bakımında hasta
ve kontrol grubu arasında anlamlı farklılık gözlenmedi
(p>0,05).
Sonuç: Çalışmamızda prolidaz aktivitesi MDB’ta sağlıklı
kişilerle benzer bulunmuştur. Bu verinin MDB ve bipolar
depresyonun farklı klinik antiteler olduğunu biyokimyasal
düzeyde gösteren bir bulgu olabileceğini önermekteyiz.
Objective: Prolidase enzyme, which exists in plasma, brain and various organs, is a cytosolic exopeptidase, that divisor the imidodipeptides with carboxyl terminal position of proline and hydroxyproline. The aim of the present study was to investigate serum prolidase activity level in major depressive disorder (MDD). Methods: This study included 22 patients with MDD as the study group, and 26 healthy subjects without any psychiatric disorders as the control group. Each patient underwent a detailed diagnostic evaluation by experienced psychiatrists. The sociodemographic information form given to both patients and the control subjects, while Hamilton Depression Scale Scoring (HDS), Hamilton Anxiety Scale Scoring (HAS), Clinical Global Impression Scoring (CGI) applied to patients. Blood samples were obtained for biochemical analyses. Results: The mean age of the patient group was 31.3±10.1 years old, whereas the mean age of the control group was 32.3±8.8 years old. The mean duration of the education for the patient group was 8.1±6.2 years, whereas for the control group was 10.2±3.8 years. There was no significant differences in terms of the mean age of participants and the mean duration of the education between two groups (p>0.05). The level of prolidase activity of patient group was 510.3±480.8 U/L, whereas the level of prolidase activity of control group was 457.8±386.0 U/L. No significant difference was observed in serum prolidase activity between patient and the control groups (p>0.05). Conclusion: In our study similar level of prolidase activity was found in MDD and healthy subjects. We suggest that this finding may be an evidence indicating that MDD and bipolar depression may be different clinical entities. J Clin Exp Invest 2015; 6 (3): 296-300.
Objective: Prolidase enzyme, which exists in plasma, brain and various organs, is a cytosolic exopeptidase, that divisor the imidodipeptides with carboxyl terminal position of proline and hydroxyproline. The aim of the present study was to investigate serum prolidase activity level in major depressive disorder (MDD). Methods: This study included 22 patients with MDD as the study group, and 26 healthy subjects without any psychiatric disorders as the control group. Each patient underwent a detailed diagnostic evaluation by experienced psychiatrists. The sociodemographic information form given to both patients and the control subjects, while Hamilton Depression Scale Scoring (HDS), Hamilton Anxiety Scale Scoring (HAS), Clinical Global Impression Scoring (CGI) applied to patients. Blood samples were obtained for biochemical analyses. Results: The mean age of the patient group was 31.3±10.1 years old, whereas the mean age of the control group was 32.3±8.8 years old. The mean duration of the education for the patient group was 8.1±6.2 years, whereas for the control group was 10.2±3.8 years. There was no significant differences in terms of the mean age of participants and the mean duration of the education between two groups (p>0.05). The level of prolidase activity of patient group was 510.3±480.8 U/L, whereas the level of prolidase activity of control group was 457.8±386.0 U/L. No significant difference was observed in serum prolidase activity between patient and the control groups (p>0.05). Conclusion: In our study similar level of prolidase activity was found in MDD and healthy subjects. We suggest that this finding may be an evidence indicating that MDD and bipolar depression may be different clinical entities. J Clin Exp Invest 2015; 6 (3): 296-300.
Açıklama
Anahtar Kelimeler
Major depresif bozukluk, Prolidaz aktivitesi, Etyoloji, Major depressive disorder, Prolidase activity, Etiology
Kaynak
Journal of Clinical and Experimental Investigations
WoS Q Değeri
Scopus Q Değeri
Cilt
6
Sayı
3
Künye
Demir, S., İbiloğlu, A. O., Güneş, M., Bulut, M., Atli, A., Kaya, M. C. ve diğerleri. (2015). Major depresif bozuklukta prolidaz aktivitesi. Journal of Clinical and Experimental Investigations, 6(3), 296-300.
