A detailed biological and chemical investigation of sixteen schillea species' essential oils via chemometric approach

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dc.contributor.authorYener, İsmail
dc.contributor.authorYılmaz, Mustafa Abdullah
dc.contributor.authorÖlmez, Özge Tokul
dc.contributor.authorAkdeniz, Mehmet
dc.contributor.authorTekin, Fetullah
dc.contributor.authorHaşimi, Nesrin
dc.contributor.authorAlkan, Mehmet Hüseyin
dc.contributor.authorÖztürk, Mehmet
dc.contributor.authorErtaş, Abdülselam
dc.contributor.orcid0000-0002-2093-4949
dc.contributor.orcid0000-0001-8932-4535
dc.contributor.orcid0000-0002-0988-9462
dc.contributor.orcid0000-0002-4090-7227
dc.contributor.orcid0000-0002-0761-6436
dc.contributor.orcid0000-0002-2193-8386
dc.date.accessioned2024-04-24T15:59:21Z
dc.date.available2024-04-24T15:59:21Z
dc.date.issued2020
dc.departmentDicle Üniversitesi, Eczacılık Fakültesi, Temel Eczacılık Bilimleri Bölümü, Analitik Kimya Ana Bilim Dalıen_US
dc.description.abstractRepresentatives of the Achillea genus are widely used as foods or nutraceuticals. Considering the increasing demand for herbal dietary supplements with health promoting effects, the objective of this research was to evaluate the chemical composition and biological activities of the essential oils obtained from sixteen Achillea species (A. biebersteinii, A. wilhelmsii subsp. wilhelmsii, A. aleppica subsp. zederbaueri, A. vermicularis, A. monocephala, A. nobilis, A. goniocephala, A. sintenisii, A. coarctata, A. kotschyi subsp. kotschyi, A. millefolium subsp. millefolium, A. lycaonica, A. spinulifolia, A. teretifolia, A. setacea, and A. schischkinii). Anticholinesterase, antiurease, antityrosinase enzymes inhibition, antioxidant, antimicrobial, toxic and cytotoxic activities of obtained essential oils were investigated. DPPH activities were found to be very low in all studied samples, while ABTS and CUPRAC antioxidant activities were found to be moderate. In addition, all samples were found to have moderate anticholinesterase and antimicrobial effects. It has been determined that the studied species have low cytotoxicity and high toxicity. Besides, chemical composition of the essential oils were determined by GC/MS and the results were chemometrically analyzed. The chemometric analyses of Achillea species collected from nine different regions were accomplished by principal component analysis (PCA) and hierarchical cluster analysis (HCA) techniques. According to the PCA analysis, A. nobilis subsp. neilreichii was found to be different from all studied species in terms of essential oil composition. The major components found in these species were piperitone, camphor, alpha-terpinene, eucalyptol, artemisia ketone, endo-borneol, beta-eudesmol and verbenol. The fact that camphor was toxic and found in majority of the studied species stands out as a remarkable result.en_US
dc.identifier.citationYener, İ., Yılmaz, M. A., Ölmez, Ö. T., Akdeniz, M., Tekin, F., Haşimi, N. ve diğerleri. (2020). A detailed biological and chemical investigation of sixteen schillea species' essential oils via chemometric approach. Chemistry and Biodiversity, 17(3), 1-12.
dc.identifier.doi10.1002/cbdv.201900484
dc.identifier.endpage12
dc.identifier.issn1612-1872
dc.identifier.issn1612-1880
dc.identifier.issue3en_US
dc.identifier.pmid31999042
dc.identifier.scopus2-s2.0-85079737581
dc.identifier.scopusqualityQ3
dc.identifier.startpage1
dc.identifier.urihttps://doi.org/10.1002/cbdv.201900484
dc.identifier.urihttps://hdl.handle.net/11468/14000
dc.identifier.urihttps://onlinelibrary.wiley.com/doi/10.1002/cbdv.201900484
dc.identifier.volume17en_US
dc.identifier.wosWOS:000514483800001
dc.identifier.wosqualityQ3
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.indekslendigikaynakPubMed
dc.institutionauthorYener, İsmail
dc.institutionauthorYılmaz, Mustafa Abdullah
dc.institutionauthorAlkan, Mehmet Hüseyin
dc.institutionauthorErtaş, Abdülselam
dc.language.isoenen_US
dc.publisherWiley-V C H Verlag Gmbhen_US
dc.relation.ispartofChemistry & Biodiversity
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAchilleaen_US
dc.subjectChemometric approachen_US
dc.subjectBiological activityen_US
dc.subjectCytotoxicityen_US
dc.subjectEssential oilen_US
dc.subjectGcen_US
dc.subjectMsen_US
dc.titleA detailed biological and chemical investigation of sixteen schillea species' essential oils via chemometric approachen_US
dc.titleA detailed biological and chemical investigation of sixteen schillea species' essential oils via chemometric approach
dc.typeArticleen_US

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