Protective Effect of L-Glutamine as an Antioxidant Against the Toxic Effects of the Pesticide Deltamethrin in the Rat Ovary

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dc.contributor.authorAgacayak, Elif
dc.contributor.authorTunc, Senem Yaman
dc.contributor.authorGoruk, Neval Yaman
dc.contributor.authorEkinci, Aysun
dc.contributor.authorBasaranoglu, Serdar
dc.contributor.authorEkinci, Cenap
dc.contributor.authorDeveci, Engin
dc.date.accessioned2024-04-24T17:37:52Z
dc.date.available2024-04-24T17:37:52Z
dc.date.issued2016
dc.departmentDicle Üniversitesien_US
dc.description.abstractOBJECTIVE: To investigate the potential protective effect of L-glutamine as an antioxidant against the toxic effects of the pesticide deltamethrin (DLM) by examining biochemical and histopathological parameters in the rat ovary. STUDY DESIGN: The rats included in this study were divided into 4 groups (n= 10) as follows: Group I, controls (distilled water, 10 mL/kg, p.o.); Group II, Lglutamine (1.5 g/kg, p.o.); Group III, DLM ( 35 mg/kg, p.o.); and Group IV, DLM (35 mg/kg, p.o.)+ Lglutamine (1.5 g/kg, p. o.). Biochemical measurements were taken and apoptotic changes were determined in ovarian tissue. Immunohistochemical expression of proliferating cell nuclear antigen and CD34 were assessed. RESULTS: Histopathological examination revealed germinal epithelial thinning and degeneration in antral follicles as well as apoptotic changes in the DLM group. The same examination showed significantly elevated estradiol (E2) levels and decreased total oxidant status levels in the DLM+ L-glutamine group as compared to the control group ( p= 0.047 and p= 0.048, respectively). Bivariate analysis resulted in the observation that E2 levels correlated negatively with follicular degeneration and vascular hemorrhage (r=-0.471* [ p= 0.036] and r=-0.482* [ p= 0.031], respectively) as well as with CD34 expression in pre-antral and antral follicles (r=0.537** [ p= 0.005]). CONCLUSION: L-glutamine as an antioxidant might alleviate the toxic effect of the pesticide DLM. (Anal Quant Cytopathol Histpathol 2016; 38: 331-342)en_US
dc.identifier.endpage342en_US
dc.identifier.issn0884-6812
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85008668659
dc.identifier.scopusqualityQ4
dc.identifier.startpage331en_US
dc.identifier.urihttps://hdl.handle.net/11468/21220
dc.identifier.volume38en_US
dc.identifier.wosWOS:000398130700002
dc.identifier.wosqualityQ4
dc.indekslendigikaynakWeb of Science
dc.indekslendigikaynakScopus
dc.language.isoenen_US
dc.publisherSci Printers & Publ Incen_US
dc.relation.ispartofAnalytical and Quantitative Cytopathology and Histopathology
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectButoxen_US
dc.subjectDecamethrinen_US
dc.subjectDeltamethrinen_US
dc.subjectGlutamineen_US
dc.subjectInsecticidesen_US
dc.subjectL-Glutamineen_US
dc.subjectNitrilesen_US
dc.subjectOvariesen_US
dc.subjectOvaryen_US
dc.subjectPesticidesen_US
dc.subjectRaten_US
dc.titleProtective Effect of L-Glutamine as an Antioxidant Against the Toxic Effects of the Pesticide Deltamethrin in the Rat Ovaryen_US
dc.titleProtective Effect of L-Glutamine as an Antioxidant Against the Toxic Effects of the Pesticide Deltamethrin in the Rat Ovary
dc.typeArticleen_US

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