Göbek kordonu kan ve stromal kökenli hücrelerin sinir hücrelerine farklılaşması
Yükleniyor...
Tarih
2007
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Dicle Üniversitesi Tıp Fakültesi
Erişim Hakkı
Attribution-NonCommercial 3.0 United States
info:eu-repo/semantics/openAccess
info:eu-repo/semantics/openAccess
Özet
Kök hücrelerin en temel özellikleri sürekli kendilerini yenilemeleriyle
beraber birçok hücre ve doku tiplerine diferansiye olma kapasiteleridir.
Göbek kordonu kanı insan hemapoetik kök hücre transplantasyonu için
kemik iliğine alternatif kaynaktır. Wharton jelinin kolayca elde edilebilir ve
in vitro büyütülebilir, kültüre edilebilir olması nöral hücrelere farklılaşması
için indüklenebilir olduğunu göstermiştir. Yapılan çalışmalarda önceki
tahminlerin aksine kan kök hücrelerinin sadece kan hücrelerine değil
çevreden aldıkları sinyaller üzerine gelişerek sinir hücresi, kas hücresi gibi
değişik beden hücrelerine dönüşebilme yeteneğine sahip oldukları
anlaşılmıştır. Kordon kanından elde edilen nöral hücreler büyük oranda
kendiliğinden oligodentrositlere diferansiye olurlar. Embriyonik kök
hücreler retinoik asit veya bazik fibroblast büyüme faktörü tedavisiyle
nöronlara ve glia hücrelerine diferansiye olmaya indüklenebilir. Motor
Nöron Hastalığı, Parkinson ve Alzheimer gibi hastalıklar ile omurilik
zedelenmeleri ve felçler kordon kanı kök hücreleri nakli ile tedavi edilmeye
çalışılmaktadır.
The most basic properties of stem cells are the capacities to self-renew indefinitely and to differentiate into multiple cell or tissue types. Umbilical cord blood has been utilized for human hematopoietic stem cell transplantation as an alternative source to bone marrow.The experiments show that Wharton’sjelly cells are easily attainable and can be expanded in vitro, maintained in culture, and induced to differentiate into neural cells. Almost recent studies it has been discovered that the cord blood-derived cells can differantiate not only to blood cells but also to various somatic cells like neuron or muscle cell with the signals taken from the envoirenment. Interestingly, neural cells obtained from umbilical cord blood show a relatively high spontaneous differentiation into oligodendrocytes, Embryonic stem cells proliferate indefinitely and can differentiate spontaneously into all tissue types.It has been shown that embryonic stem cells can be induced to differentiate into neurons and glia by treatment with retinoic acid or basic fibroblast growth factor. It has been studied that the diseases as Motor Neuron Disease, Parkinson, Alzheimer and degeneration of medulla spinalis and also paralysises could be treated with transplantation of cord blood-dericed stem cells.
The most basic properties of stem cells are the capacities to self-renew indefinitely and to differentiate into multiple cell or tissue types. Umbilical cord blood has been utilized for human hematopoietic stem cell transplantation as an alternative source to bone marrow.The experiments show that Wharton’sjelly cells are easily attainable and can be expanded in vitro, maintained in culture, and induced to differentiate into neural cells. Almost recent studies it has been discovered that the cord blood-derived cells can differantiate not only to blood cells but also to various somatic cells like neuron or muscle cell with the signals taken from the envoirenment. Interestingly, neural cells obtained from umbilical cord blood show a relatively high spontaneous differentiation into oligodendrocytes, Embryonic stem cells proliferate indefinitely and can differentiate spontaneously into all tissue types.It has been shown that embryonic stem cells can be induced to differentiate into neurons and glia by treatment with retinoic acid or basic fibroblast growth factor. It has been studied that the diseases as Motor Neuron Disease, Parkinson, Alzheimer and degeneration of medulla spinalis and also paralysises could be treated with transplantation of cord blood-dericed stem cells.
Açıklama
Anahtar Kelimeler
Göbek kordonu kanı, Wharton peltesi, Nöronal farklılaşma, Kök hücre, Umblical cord blood, Wharton gelly, Neuronal differentiation, Stem cell
Kaynak
Dicle Tıp Dergisi
WoS Q Değeri
Scopus Q Değeri
Cilt
34
Sayı
3
Künye
Baran, Ö.P., Nergiz, Y. ve Bahçeci, S. (2007). Göbek kordonu kan ve stromal kökenli hücrelerin sinir hücrelerine farklılaşması. Dicle Tıp Dergisi, 34(3), 233-238.
