The effects of exogenous epidermal growth factor on the sialoadenectomized rat liver

The aim of the present study was to determine endogenous Epidermal Growth Factor (EGF) deficiency with sialoadenectomy and exogenous EGF administration effects on electron microscopic changes in a rat liver. After 27 days sialoadenectomy, transmission electron microscope evaluation indicated that the liver of sialoadenectomy plus exogenous EGF administration group had similar ultrastructural appearance as the control group. This study indicated that short term exogenous EGF supplementation in sialoadenectomized rats can relatively improve liver ultra structure.