Yazar "Tunc, S. Y." seçeneğine göre listele

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    Clinical experience in pregnancies complicated by adnexal torsion
    (7847050 Canada Inc, 2016) Basaranoglu, S.; Agacayak, E.; Tunc, S. Y.; Icen, M. S.; Turgut, A.; Peker, N.; Evsen, M. S.
    Objective: The purpose of this study was to present data on clinical and operational management and postoperative outcomes of pregnancies complicated by adnexal torsion (AT). Materials and Methods: Twenty-four pregnant women who presented to the present clinic between January 2007 to December 2013 and were intraoperatively diagnosed with AT were included in this study. Demographic data such as age and data on obstetric history, gestational week, current trimester, previous gynecologic and non-gynecologic operations, type of surgery that was performed, average size, location and number of adnexal masses, surgical techniques that were employed, postoperative complications, and pathology results were investigated and noted. Results: In this study, 132 patients were operated due to AT, and the rate of pregnant women with AT was 18.2% (24/132). The mean age of the patients was 29.25 +/- 6.27 years, and the mean gestational week was 18.25 +/- 7. Eight patients were in their first trimester (33.3%) whereas 13 were in their second trimester (54.2%), and three were in their third trimester (12.5%) when they presented to the hospital. The mean AT size was 95.3 +/- 53.9 mm, as measured by ultrasonography. All the patients were operated by laparotomy. Regarding the types of abdominal incision, 13 patients (54.2%) had a Pfannenstiel incision, three patients (12.5%) had an infra-umbilical median incision, and eight patients (33.3%) had a pararectal incision. Duration of operation was significantly shorter in patients with pararectal incisions (p < 0.01) compared to those with Pfannenstiel and infra-umbilical median incisions. Regarding the types of treatment, ten patients (41.7%) underwent unilateral salpingo-oophorectomy (USO), eight patients (33.3%) underwent adnexal detorsion+cystectomy, and six patients (25%) underwent adnexal detorsion only. Conclusion: AT is a gynecologic emergency that requires early diagnosis and treatment, as it is capable of complicating the pregnancy. Determination of the current gestational week prior to the surgical intervention will assist and guide the surgeon in identifying the suitable type of surgery for a particular patient. Pararectal incision should be the incision of choice for a shorter duration of operation, which is crucial in pregnant women for reduced exposure to anesthesia.
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    Copper, ceruloplasmin and oxidative stress in patients with advanced-stage endometriosis
    (Verduci Publisher, 2013) Turgut, A.; Ozler, A.; Goruk, N. Y.; Tunc, S. Y.; Evliyaoglu, O.; Gul, T.
    AIM: To compare patients with advanced stage endometriosis with control patients without endometriosis with respect to serum Copper (Cu) and Ceruloplasmin (Cp) levels and oxidative stress markers in order to evaluate the importance of these parameters in the pathogenesis of endometriosis. PATIENTS AND METHODS: A total of 72 women who underwent laparoscopy or laparotomy for evaluation of infertility, pelvic pain, pelvic mass, tubal ligation or endometriosis were enrolled for this prospective clinical study. Patients were divided into two groups by visual diagnosis at surgery and histological confirmation of endometriosis: control patients (n=41) without endometriosis and study group (n=31) with stage III/IV (advanced stage) endometriosis. Serum Cu, Cp, total antioxidant status (TAS), total oxidant status (TOS), oxidative stress index (OSI), paraoxonase-1 (PON-1), malondialdehyde (MDA), triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL) and low-density lipoprotein (LDL) levels were compared between the two groups. Correlations between Cu, Cp and oxidative stress markers were determined. RESULTS: Serum TOS, OSI, Cu, Cp, TG, TC, LDL were significantly higher, whereas TAS, PON-1 activity and HDL were significantly lower, in women with advanced-stage endometriosis than in control groups. There was no difference in serum MDA activities between the two groups. Positive correlations were found between Cu and TOS, Cu and OSI, Cu and Cp, while a negative correlation was found between Cu and PON-1 in the advanced-stage endometriosis group. Positive correlations were found between Cp and TOS, and Cp and OSI in the advanced-stage endometriosis group. CONCLUSIONS: Cu and Cp appear to be associated with the etiopathogenesis of and oxidative stress in endometriosis.
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    Effects of estrogen, estrogen/progesteron combination and genistein treatments on oxidant/antioxidant status in the brain of ovariectomized rats
    (Verduci Publisher, 2013) Evsen, M. S.; Ozler, A.; Gocmez, C.; Varol, S.; Tunc, S. Y.; Akil, E.; Uzar, E.
    INTRODUCTION: The aim of this study was to investigate the antioxidative effects of estradiol (E), E plus progesteron (P) combination (E/P) and genistein (G) treatment in the brain of ovariectomized (OVX) rats. MATERIALS AND METHODS: Adult female Sprague-Dawley rats were divided into five groups, with each group including ten rats. Rats were anesthetized and bilateral ovariectomy was performed under general anaesthesia in all groups except for the sham operation group. Groups included: Sham-operated, control (OVX), estrogen treated group (OVX+ E), E/P combination group (OVX+ E/P) and G treated group (OVX+ G). Treatments were applied for 8 weeks. The total anti-oxidant status (TAS), total oxidant status (TOS), nitric oxide level (NO), glutathione peroxidase activity (GSH-Px) and oxidative stress index (OSI) were analysed in the brain tissue of rats from each treatment category. RESULTS: Ovariectomy lead to an increase in brain TOS and OSI levels compared to the sham group (p < 0.05). Also, ovariectomy resulted in a decrease in brain TAS levels compared to the sham group that approached statistical significance (p = 0.078). Significant decreases in TOS, OSI, GSH-Px and a significant increases in TAS and NO levels were observed in the E-treatment group compared to the control group (p < 0.001). The E/P combination group exhibited a significantly decreased TOS and OSI and significantly increased TAS and NO levels relative to the control group (p < 0.05). Genistein treatment resulted in a significant decrease in TOS and OSI compared to the control group (p < 0.05). CONCLUSIONS: Oxidative stress markers increase in the brain tissue of OVX rats. Conversely, estradiol, E/P and G supplementation decreases oxidative stress markers and increases antioxidant activity. Using G may prevent neural pathologies result in menopause-related oxidative stress.
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    Expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in the endometrium of patients with repeated implantation failure after in vitro fertilization
    (Verduci Publisher, 2014) Turgut, A.; Goruk, N. Y.; Tunc, S. Y.; Agaçayak, E.; Alabalik, U.; Yalinkaya, A.; Gul, T.
    AIM: To compare the immunohistochemical expression of extracellular matrix metalloproteinase inducer (EMMPRIN) in repeated implantation failure (RIF) patients with normal fertile controls. PATIENTS AND METHODS: The study group consisted of primary infertile patients with RIF and normal fertile controls between January 2011 and February 2013. Endometrial samples received at the luteal phase were exposed to immunohistochemical staining for EMMPRIN antibodies. EMMPRIN expression of endometrial glandular epithelial cells, stromal cells and vascular endothelial cells were evaluated. The main outcome measure was defined as immunohistochemical score with regard to the severity and extent of staining. RESULTS: The study group consisted of 26 primary infertile patients, whereas the control group consisted of 40 normal fertile controls. The fertile group was found to have stronger expression of EMMPRIN than the study group when endometrial glandular epithelial cells, stromal cells and vascular endothelial cells were evaluated with regards to the severity of staining (p < 0.001), the extent of staining (p < 0.001) and total staining score (p < 0.001). CONCLUSIONS: This is the first study showing low expression of EMMPRIN in the endometrial cells of the patients with RIF compared with fertile healthy controls. We suggest that reduced EMMPRIN expression in the human endometrium may lead to poor endometrial receptivity.
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    Increased platelet count in severe peritoneal endometriosis
    (I R O G Canada, Inc, 2014) Evsen, M. S.; Soydinc, H. E.; Sak, M. E.; Ozler, A.; Turgut, A.; Celik, Y.; Tunc, S. Y.
    Objective: Platelet count (PC) is higher in chronic inflammatory diseases. The aim of this study was to evaluate the PC in patients with severe pelvic endometriosis. Materials and Methods: Patients with advanced stage pelvic endometriosis were retrospectively evaluated in a tertiary center between January 2009 and December 2011. Patients with pelvic endometriosis were divided into two groups; advanced stage peritoneal endometriosis were classified as Group 1 (n = 28). Group 2 consisted of 29 patients which had ovarian endometrioma without clinically apparent peritoneal endometriosis foci. Group 3 included 51 women as control subjects. PC between the groups was tested by Student's t test. The mean values of three groups were analyzed by using one way ANOVA test followed post-hoc test Bonferroni. Results: PC in patients with pelvic endometriosis were found to be higher from the control group (290 +/- 67 10(9)/1; 264 63 +/- 109/1, respectively; p = 0.038). Patients with peritoneal endometriosis (Group 1) had significantly higher PCs compared with the healthy controls (309 +/- 65 109/1; 264 +/- 63 10(9)/1; respectively; p = 0.011). Conclusion: Increased PC in advanced stage pelvic endometriosis may be a sign of increased systemic inflammation. The systemic inflammation may be more apparent in advanced stage peritoneal endometriosis.
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    Serum levels of the adipokines, free fatty acids, and oxidative stress markers in obese and non-obese preeclamptic patients
    (I R O G Canada, Inc, 2015) Turgut, A.; Ozler, A.; Goruk, N. Y.; Tunc, S. Y.; Sak, M. E.; Evsen, M. S.; Evliyaoglu, O.
    Purpose of investigation: To investigate the roles of adipokines, free fatty acid (FFA), and oxidative stress in obese and non-obese preeclamptic patients. Materials and Methods: Gestational age-matched obese preeclamptic (n=32), non-obese preeclamptic (n=32),and non-obese normotensive healthy (n=32) pregnant women were included in the study. Serum insulin, insulin resistance, leptin, nesfatin, ghrelin, chemerin, FFA levels, total antioxidant status, total oxidant status, and oxidative stress index were determined. Results: Leptin and nesfatin levels were significantly lower and ghrelin levels were significantly higher in the normotensive group as compared to the preeclamptic groups, while no difference was observed between obese and non-obese preeclamptic groups. Chemerin and FFA levels were significantly higher in obese preeclamptics as compared to non-obese preeclamptics and normotensive group. Total antioxidant status (TAS) levels were significantly higher in the normotensive group as compared to the preeclamptic groups, while no difference was observed between obese and non-obese preeclamptics. Total oxidative status (TOS) and oxidative stress index (OSI) levels were significantly lower in the normotensive group as compared to the preeclamptic groups, while no difference was observed between obese and non-obese preeclamptics. Conclusion: Serum levels of adipokines, TOS, and FFAs were significantly higher in pregnants with preeclampsia as compared to non-obese normotensive controls. Chemerin and FFA levels were significantly higher in obese preeclamptics as compared to non-obese preeclamptics.
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    Significance of growth differentiation factor 15 in primary ovarian insufficiency: inflammatory, biochemical, and hormonal correlates
    (I R O G Canada, Inc, 2017) Tunc, S. Y.; Goruk, N. Y.; Agacayak, E.; Icen, M. S.; Findik, F. M.; Kusen, H.; Evsen, M. S.
    Purpose: To investigate the levels of growth differentiation factor-15 (GDF-15) in primary ovarian insufficiency (POI) and to evaluate its correlation with hormonal, biochemical, and inflammatory indicators. Materials and Methods: This comparative, cross-sectional study was carried out in 60 cases consisting of 30 healthy controls (mean age: 29.2 +/- 5.0 years) and 30 patients with POI (mean age: 28.9 +/- 6.8 years). Two groups were compared in terms of serum levels of glucose, lipids, thyroid stimulating hormone (TSH), follicle stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), prolactin (PRL), GDF-15, and neutrophil-lymphocyte ratios (NLR). Correlation between GDF-15 and NLR with these variables was sought. Results: Serum levels of FSH (p < 0.001), LH (p < 0.001), NLR (p < 0.001) and TSH (p = 0.020) were increased significantly in POI group. In POI patients, a correlation was detected between levels of GDF-15 levels and PRL (p = 0.049). Conclusion: The authors suggest that NLR can serve as a promising marker for diagnosis and follow-up of POI, whereas GDF-15 seems not to have such a potential.