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    Effects of accidental ammonium Sulphate poisoning on antioxidant / oxidant status in lambs
    (2011) Aytekin I.; Onmaz A.C.; Ulucan A.; Alp H.
    In this study, the effects of the ammonium sulphate intoxication on the blood antioxidant /oxidant status were investigated in Sakiz crossbred Iambs. For that, circulating blood urea nitrogen (BUN), nitric oxide (NO), malondialdehyde (MDA), glutathione (GSH), ?-carotene, retinol and ceruloplasmin concentrations were measured in 6 lambs accidentally poisoned with ammonium sulphate and in 6 healthy control lambs. Oral treatment with 10% glutamic acid (lg/kg), 2.5% acetic acid (2.5 mL/kg) and vitamin A (400 IU/kg) was daily administered to diseased animals for five days. Poisoned lambs exhibited neurological signs (sleepiness, ataxia, tonic and clonic spasms) coupled to a rumen atony and acceleration of heart and respiratory rates compared to healthy controls. Biochemically, the circulating MDA, NO and BUN concentrations were markedly increased and the GSH, ?-carotene and vitamin A concentrations were significantly depressed compared to healthy controls whereas the ceruloplasmin concentrations were not significantly altered. After treatment, clinical and biochemical signs were significantly alleviated but, however 2 lambs died. For them, the histopathological examinations after haematoxylin-eosin staining revealed cell degeneration in liver, lungs and kidney associated to mononuclear cell infiltrates and proliferation of Küpffer cells. These results clearly showed the occurrence of an oxidative stress induced by ammonium sulphate poisoning leading to cell damage and proved the efficiency of a treatment based on organic acids and retinol supplementation.
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    Effects of cafeic acid phenethyl ester, ellagic acid, sulforaphane and curcumin on diazinon induced damage to the lungs, liver and kidneys in an acute toxicity rat model
    (Veteriner Fakultesi Dergisi, 2011) Alp H.; Aytekin I.; Esen H.; Basarali K.; Kul S.
    The aim of this study was to investigate the possible protective efects of cafeic acid phenethyl ester (CAPE), ellagic acid (EA), sulforaphane (SFN) and curcumin (CUR) against the toxic efects of diazinon (DI). Sixty Sprague Dawley rats were randomly divided into 10 groups. Five groups were allocated as control groups comprising unmedicated control, CAPE, EA, SFN and CUR control groups. The remaining five groups were the study groups comprising DI, DI + CAPE, DI + EA, DI + SFN, and DI + CUR groups. The animals were sacrified 24 h after drug administrations. DI caused a decrease in acetyl cholinesterase (AChE) activity (P<0.05) and increases in ?-glutamyltransferase (GGT) and amylase activities. It also damaged the kidney, liver, and lung tissues. The negative efects of DI on these enzymes were confirmed histopathologically. Also, CAPE, EA, SFN and CUR reduced amylase and GGT activities and caused an increase in the AChE activities that were increased due to the toxic efects of DI. Thus, it was determined biochemically and histopathologically that these medication reduced the degenerative toxic efects created by DI in the lung, liver and kidney tissues. These findings led us to believe that CAPE, EA, SFN and CUR may be used as protective medicines in acute DI intoxication.
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    The treatment of catties with dermatofitozis via enilconazole
    (2009) Aytekin I.; Alp H.; Mamak N.; Aslan S.
    Study material consisted as 15 experiment and 8 control, totally 23 cattle that possessed by 2 breeders and together housed in Afyonkarahisar province, Suhut district, Kilickaya village; despite vaccine used two times for medicinal purpose displaying no recovery; aged at between 3 and 12 months, diagnosed as dermatofitosis by clinically and microbiological. Being clinical for dermatofitosis the animals in experiment and control groups were examined if there were lesions on the head and derm or not and was categorized as light, bland and acute according to its frequency. The clinical status were examined according to the localization, amplitude and number of lesions. During the study any change was done in condition of animal care, nutrition and shelter. The experiment group was made up 15 cattle; two of them were examined as light, five of them were examined as bland and eight of them were examined as acute and the control group was made up 8 cattle; one of them was examined as light, third of them were examined as bland, fourth of them were examined as acute. Ten percent Enilconazole solution was applied in 4 mg kg-1 dose three days apart as externally to the animals in experiment group. The first application to entire body of the animal and the subsequent 4 applications were done externally in the style of spray to the parts where the dermatofitosis lesions were appeared. The cattle in the control group weren't applied any therapy. Following the drug administration, in second and fourth weeks a decrease in the keratinized tissues and becoming pilosity were observed in the lesional parts in all experiment group animals. It was seen in the 6th week that keratinized tissues completely decreased, pilosity became dense and the healing was faster. It was determined in the 8th week that lesions recovered completely. It was seen that when any application was made to the control groups animal there were no change in dermatofitosis lesions. As a result, it was of the opinion that owing to easy using, being curative in a short time and being economic of the 10% enilconazole solution was a useful and an alternative medicine for the dermatofitosis therapy in the cattle. © Medwell Journals, 2009.