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A comparison between a combination of letrozole and clomiphene citrate versus gonadotropins for ovulation induction in infertile patients with clomiphene citrate - A resistant polycystic ovary syndrome-A retrospective study

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info:eu-repo/semantics/openAccess

Date

2020

Author

Ege, Serhat
Bademkıran, Muhammed Hanifi
Peker, Nurullah
Tahaoǧlu, Ali Emre
Çaça, Fatma Nur Hançer
Özçelik, Serap Mutlu

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Ege, S., Bademkıran, M. H., Peker, N., Tahaoǧlu, A. E., Çaça, F. N. H. ve Özçelik, S. M. (2020). A comparison between a combination of letrozole and clomiphene citrate versus gonadotropins for ovulation induction in infertile patients with clomiphene citrate - A resistant polycystic ovary syndrome-A retrospective study. Ginekologia Polska, 91(4), 185-188.

Abstract

Objectives: The aim of this study was to compare a combination treatment with CC plus letrozole versus gonadotropins in CC-resistant polycystic ovary syndrome (PCOS) patients with regard to ovulation and clinical pregnancy rate. Material and methods: One hundred sixteen CC-resistant infertile PCOS patients were evaluated retrospectively. The patients were divided into two groups. Group 1 (n = 73) received CC plus letrozole, and Group 2 (n = 43) received gonadotropins. Results: The ovulation rate in Group 1 was 65/73 (89%), the pregnancy rate was 13/73 (18%), the twin foetuses rate was 1/73 (1.3%) and the miscarriage rate was 2/73 (2.7%). In Group 2, the ovulation rate was 41/43 (95%), and the pregnancy rate was 8/43 (19%) the rate of the twin foetuses was 1/43 (2.3%) and the miscarriage rate was 1/43 (2.3%). There was no statistically significant difference in the ovulation (p = 0.25), pregnancy (p = 0.91), twin foetuses (p = 0.89) and miscarriage p = 0.89) rates between two groups. Conclusions: This new drug combination suggests that it may be a lower cost, lower risk alternative treatment that increases the rate of ovulation. Larger randomized clinical trials are needed to provide information on live birth rates of this combination.

Source

Ginekologia Polska

Volume

91

Issue

4

URI

https://journals.viamedica.pl/ginekologia_polska/article/view/66652
https://hdl.handle.net/11468/7385

Collections

  • Cerrahi Tıp Bilimleri Makaleler [157]
  • Scopus İndeksli Yayınlar Koleksiyonu [329]



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