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Serotype distribution of Streptococcus pneumonia in children with invasive disease in Turkey: 2015-2018

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info:eu-repo/semantics/openAccess

Date

2020

Author

Ceyhan, Mehmet
Aykaç, Kübra
Gürler, Nezahat G.
Özsürekçi, Yasemin
Öksüz, Lütfiye
Altay Akışoğlu, Özlem
Öz, Fatma Nur
Emiroǧlu, Melike
Türkdağı, Hatice
Yaman, Akgün
Söyletir, Güner
Öztürk, Candan
Akpolat, Nezahat Özerdem
Özakın, Cüneyt
Aydın, Faruk
Aydemir, Sabire Şöhret
Kiremitçi, Abdurrahman
Gültekin, Meral
Camcıoğlu, Yıldız
Zer, Yasemin
Güdücüoǧlu, Hüseyin
Gülay, Zeynep
Birinci, Asuman
Arabacı, Çiğdem
Karbuz, Adem
Devrim, İlker
Sorguç, Yelda
Baysan, Betil Özhak
Karadaǧ-Öncel, Eda
Yılmaz, Nisel Özkalay
Altıntop, Yasemin Ay

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Ceyhan, M., Aykaç, K., Gürler, N. G., Özsürekçi, Y., Öksüz, L., Akışoğlu, Ö. A. ve diğerleri (2020). Serotype distribution of Streptococcus pneumonia in children with invasive disease in Turkey: 2015-2018. Human Vaccines and Immunotherapeutics, 16(11), 2773-2778.

Abstract

Objectives: To determine the serotype distribution of pneumococcus causing invasive pneumococcal disease (meningitidis, bacteremia and empyema) in children in Turkey, and to observe potential changes in this distribution in time to guide effective vaccine strategies. Methods: We surveyed S. pneumoniae with conventional bacteriological techniques and with real-time polymerase chain reaction (RT-PCR) in samples of cerebrospinal fluid (CSF), blood and pleural fluid. S. pneumoniae strains were isolated from 33 different hospitals in Turkey, which are giving health services to approximately 60% of the Turkish population. Results: A total of 167 cases were diagnosed with invasive pneumococcal disease between 2015 and 2018. We diagnosed 52 (31.1%) patients with meningitis, 104 (62.2%) patients with bacteremia, and 11 (6.6%) patients with empyema. Thirty-three percent of them were less than 2 years old and 56% less than 5 years old. Overall PCV13 serotypes accounted for 56.2% (94/167). The most common serotypes were 19 F (11.9%), 1 (10.7%) and 3 (10.1%). Conclusions: Besides the increasing frequency of non-vaccine serotypes, vaccine serotypes continue to be a problem for Turkey despite routine and high-rate vaccination with PCV13 and significant reduction reported for the incidence of IPD in young children. Since new candidate pneumococcal conjugate vaccines with more serotype antigens are being developed, continuing IPD surveillance is a significant source of information for decision-making processes on pneumococcal vaccination.

Source

Human Vaccines and Immunotherapeutics

Volume

16

Issue

11

URI

https://www.tandfonline.com/doi/full/10.1080/21645515.2020.1747931
https://hdl.handle.net/11468/7337

Collections

  • Scopus İndeksli Yayınlar Koleksiyonu [291]
  • Temel Tıp Bilimleri Makaleler [49]



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